Исследование Уремического Синдрома Через Экспериментальные Модели На Крысах
Keywords:
Экспериментальный уремический синдром, Крыса, 5/6 уменьшение паренхимы почек, Анализ крови и мочи, Вторичный гиперпаратиреоз
Abstract
Хронический уремический синдром был вызван 5/6 нефрэктомией, а острый уремический синдром - двусторонней нефрэктомией у крыс. При хроническом уремическом синдроме анализ крови и мочи показал высокий уровень азота мочевины (BUN) и креатинина. Кроме того, были обнаружены химические признаки, характерные для вторичной гиперпаратиреоза. Животные страдали от сильной полиурии, протеинурии и альбуминурии, однако, уровень общего белка в крови был увеличен, что вызвало удивление. Экспериментальный хронический уремический синдром представляет собой "синдром экстремальной адаптации" регуляторной активности оставшейся паренхимы почек и всего организма. В отличие от этого, острый уремический синдром, вызванный двусторонней нефрэктомией, представляет собой тяжелое нарушение обмена воды и электролитов, в конечном итоге приводящее к смерти экспериментальных животных через 50-60 часов.
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References
1. Arrizurieta de Muchnik, E. E., Lipham, E. M., Gottschalk, C. W.: Structure and function in normal and enlarged nephrons. In: Compensatory kidney hypertrophy, Nowinski, W. W., Gross, R. J., Eds., pp. 29--44. New York-London: Academic Press 2009.
2. Bergstroem, J., Bittar, E. E.: The foundation of uremic toxicity. In: The biological basis of medicine, Bittar, E. E., Bittar, N., Eds., Vol. 6, pp. 495--544. London-New York: Academic Press 2009.
3. Bonvalet, J.-P., Champion, M., Wanstock, F., Berjal, G.: Enlargement of renal size in young rats: Increase in the number of nephrons. Kidney International 1, 391--396 (2012).
4. Bricker, N. S.: The significance of the intact nephron hypothesis. American Journal of Medicine 46, 1--11 (2009).
5. Bricker, N. S., Klahr, S., Lubowith, H., Rieselbach, R. E.: Renal function in chronic kidney disease. Medicine (Baltimore) 44, 263--288 (2005).
6. Bricker, N. S., Klahr, S., Rieselbach, R. E.: The functional adaptation of the diseased kidney. Part I: Glomerular filtration rate. Journal of Clinical Investigation 43, 1915--1921 (2004).
7. Bricker, N. S., Morrin, P. A. F., Kime, S. W., Jr.: The pathophysiology of chronic Bright's disease: An explanation of the intact nephron hypothesis. American Journal of Medicine 28, 77--98 (2000).
8. Chanutin, A., Ferris, E. B.: Experimental renal insufficiency produced by partial nephrectomy. Archives of Internal Medicine 49, 767--787 (1982).
9. Dobbelstein, R.: Pathogenesis of uremia. Internist 12, 76--84 (2011).
10. Hansson, C. G., Mathewson, S., Norrby, K.: Growth and proliferation of parathyroid cells in nephrectomized rats. Pathologica Europaea 6, 313--321 (2011).
11. Hayslett, J. P., Kashgarian, M., Epstein, F. I.: Functional correlates of compensatory renal hypertrophy. Journal of Clinical Investigation 47, 774--782 (2008).
12. Heitz, Ph.: Experimental uremic syndrome. Histological, immunofluorescence-optical, ultrastructural, morphometric, and biochemical investigations. Habilitation Thesis, Basel 2013.
13. Heitz, Ph., Meier, P., Riede, U. N.: Ultrastructural-morphometric changes in liver parenchymal cells of rats with experimental chronic uremic syndrome. Pathologica Europaea 6, 433--444 (2011).
14. Morrison, A. B.: The regulation of calcium and phosphate metabolism. American Journal of Medicine 32, 77--92 (2002).
15. Ohnaeker, R., Schloot, W.: Fibroosteoclasia following 5/6 reduction of renal parenchyma in rats. Nephrology Dialysis Transplantation 8, 773--779 (2021).
16. Pappenheimer, J. R.: Influence of chronic renal disease on calcium and phosphorus metabolism. American Journal of Physiology 117, 1--16 (1996).
17. Shimamura, T., Morrison, A. B.: Parathyroid hyperplasia in rats with chronic uremia. American Journal of Pathology 56, 1--21 (2009).
18. Wright, F. S., Giebisch, G.: Intrarenal mechanisms for regulation of calcium and magnesium excretion. Kidney International 2, 93--108 (2012).
19. Kimmich, G. A., Rasmussen, H.: Calcium-mediated regulation of pyruvate carboxylase activity in intact rat liver mitochondria. Journal of Biological Chemistry 244, 190--199 (2009).
20. Morgan, J. M., Morgan, T. E., Thomas, G. E.: Inhibition of lactic dehydrogenase by ultrafiltrate of uremic blood. Metabolism 12, 1051--1053 (2003).
21. Morrison, A. B.: Experimentally induced chronic renal insufficiency in the rat. Laboratory Investigation 11, 321--332 (2002).
22. Morrison, A. B.: Experimental chronic renal insufficiency. In: Methods and achievements in experimental pathology, Bajusz, E., Jasmin, G., Eds., Vol. 1, pp. 455--475. Basel-New York: Karger 2006.
23. Morrison, A. B., Howard, T. M.: The functional capacity of hypertrophied nephrons. Effect of partial nephrectomy on the clearance of Inulin and PAH in the rat. Journal of Experimental Medicine 123, 829--844 (2006).
24. Ohnacker, H., Heitz, Ph., Lemagen, W.: Morphometric analysis of bone in experimental chronic uremia in the rat. In preparation.
25. Pappenheimer, A. M.: The effect of experimental reduction of kidney substance upon the parathyroid glands and skeletal tissue. Journal of Experimental Medicine 88, 965--979 (1986).
26. Platt, T., Roscoe, M. H., Smith, F. W.: Experimental renal failure. Clinical Science 11, 217--231 (1992).
27. Relman, A. S.: Metabolic consequences of acid-base disorders. Kidney International 1, 347--359 (2012).
28. Lemagen, W., Heitz, Ph., Weidmann, P., Schnoppler, J., Ohnacker, H., Luethy, H., del Pozo, E.: Comparative kinetics of 45Ca and 85Sr in chronic uremic syndrome in the rat. Calcified Tissue Research (submitted for publication).
29. Denner, D. H. P.: Zellstoffwechselstörungen bei Uraemie. Habil.-Schr., Aachen 1968.
30. Shimamura, T., Morrison, A. B.: Glomerular sclerosis following hypertrophy induced by partial 5/6-nephrectomy in rats (abstract). Federation Proceedings 28, 620 (2009).
31. Teschan, P. E.: On the pathogenesis of uremia. American Journal of Medicine 48, 671--677 (2010).
32. Wright, F. S., Giebisch, G.: Glomerular filtration in single nephrons. Kidney International 1, 201--209 (2012).
2. Bergstroem, J., Bittar, E. E.: The foundation of uremic toxicity. In: The biological basis of medicine, Bittar, E. E., Bittar, N., Eds., Vol. 6, pp. 495--544. London-New York: Academic Press 2009.
3. Bonvalet, J.-P., Champion, M., Wanstock, F., Berjal, G.: Enlargement of renal size in young rats: Increase in the number of nephrons. Kidney International 1, 391--396 (2012).
4. Bricker, N. S.: The significance of the intact nephron hypothesis. American Journal of Medicine 46, 1--11 (2009).
5. Bricker, N. S., Klahr, S., Lubowith, H., Rieselbach, R. E.: Renal function in chronic kidney disease. Medicine (Baltimore) 44, 263--288 (2005).
6. Bricker, N. S., Klahr, S., Rieselbach, R. E.: The functional adaptation of the diseased kidney. Part I: Glomerular filtration rate. Journal of Clinical Investigation 43, 1915--1921 (2004).
7. Bricker, N. S., Morrin, P. A. F., Kime, S. W., Jr.: The pathophysiology of chronic Bright's disease: An explanation of the intact nephron hypothesis. American Journal of Medicine 28, 77--98 (2000).
8. Chanutin, A., Ferris, E. B.: Experimental renal insufficiency produced by partial nephrectomy. Archives of Internal Medicine 49, 767--787 (1982).
9. Dobbelstein, R.: Pathogenesis of uremia. Internist 12, 76--84 (2011).
10. Hansson, C. G., Mathewson, S., Norrby, K.: Growth and proliferation of parathyroid cells in nephrectomized rats. Pathologica Europaea 6, 313--321 (2011).
11. Hayslett, J. P., Kashgarian, M., Epstein, F. I.: Functional correlates of compensatory renal hypertrophy. Journal of Clinical Investigation 47, 774--782 (2008).
12. Heitz, Ph.: Experimental uremic syndrome. Histological, immunofluorescence-optical, ultrastructural, morphometric, and biochemical investigations. Habilitation Thesis, Basel 2013.
13. Heitz, Ph., Meier, P., Riede, U. N.: Ultrastructural-morphometric changes in liver parenchymal cells of rats with experimental chronic uremic syndrome. Pathologica Europaea 6, 433--444 (2011).
14. Morrison, A. B.: The regulation of calcium and phosphate metabolism. American Journal of Medicine 32, 77--92 (2002).
15. Ohnaeker, R., Schloot, W.: Fibroosteoclasia following 5/6 reduction of renal parenchyma in rats. Nephrology Dialysis Transplantation 8, 773--779 (2021).
16. Pappenheimer, J. R.: Influence of chronic renal disease on calcium and phosphorus metabolism. American Journal of Physiology 117, 1--16 (1996).
17. Shimamura, T., Morrison, A. B.: Parathyroid hyperplasia in rats with chronic uremia. American Journal of Pathology 56, 1--21 (2009).
18. Wright, F. S., Giebisch, G.: Intrarenal mechanisms for regulation of calcium and magnesium excretion. Kidney International 2, 93--108 (2012).
19. Kimmich, G. A., Rasmussen, H.: Calcium-mediated regulation of pyruvate carboxylase activity in intact rat liver mitochondria. Journal of Biological Chemistry 244, 190--199 (2009).
20. Morgan, J. M., Morgan, T. E., Thomas, G. E.: Inhibition of lactic dehydrogenase by ultrafiltrate of uremic blood. Metabolism 12, 1051--1053 (2003).
21. Morrison, A. B.: Experimentally induced chronic renal insufficiency in the rat. Laboratory Investigation 11, 321--332 (2002).
22. Morrison, A. B.: Experimental chronic renal insufficiency. In: Methods and achievements in experimental pathology, Bajusz, E., Jasmin, G., Eds., Vol. 1, pp. 455--475. Basel-New York: Karger 2006.
23. Morrison, A. B., Howard, T. M.: The functional capacity of hypertrophied nephrons. Effect of partial nephrectomy on the clearance of Inulin and PAH in the rat. Journal of Experimental Medicine 123, 829--844 (2006).
24. Ohnacker, H., Heitz, Ph., Lemagen, W.: Morphometric analysis of bone in experimental chronic uremia in the rat. In preparation.
25. Pappenheimer, A. M.: The effect of experimental reduction of kidney substance upon the parathyroid glands and skeletal tissue. Journal of Experimental Medicine 88, 965--979 (1986).
26. Platt, T., Roscoe, M. H., Smith, F. W.: Experimental renal failure. Clinical Science 11, 217--231 (1992).
27. Relman, A. S.: Metabolic consequences of acid-base disorders. Kidney International 1, 347--359 (2012).
28. Lemagen, W., Heitz, Ph., Weidmann, P., Schnoppler, J., Ohnacker, H., Luethy, H., del Pozo, E.: Comparative kinetics of 45Ca and 85Sr in chronic uremic syndrome in the rat. Calcified Tissue Research (submitted for publication).
29. Denner, D. H. P.: Zellstoffwechselstörungen bei Uraemie. Habil.-Schr., Aachen 1968.
30. Shimamura, T., Morrison, A. B.: Glomerular sclerosis following hypertrophy induced by partial 5/6-nephrectomy in rats (abstract). Federation Proceedings 28, 620 (2009).
31. Teschan, P. E.: On the pathogenesis of uremia. American Journal of Medicine 48, 671--677 (2010).
32. Wright, F. S., Giebisch, G.: Glomerular filtration in single nephrons. Kidney International 1, 201--209 (2012).
Published
2023-10-09
How to Cite
Ш. А. Абдулхакимов, & Хасанова Д. А. (2023). Исследование Уремического Синдрома Через Экспериментальные Модели На Крысах. Central Asian Journal of Theoretical and Applied Science, 4(10), 33-38. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1295
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