Bioactive of Adiponectin in Metabolic Diseases a Review Article
Keywords:
Adiponectin Metabolic Syndrome Insulin Resistance, Diabetes Type 2
Abstract
The current study demonstrates adiponectin role in pathogenesis also as a biomarker diagnostic indicator with metabolic syndrome and insulin resistance( IR). Adiponectin is Lipoprotein secreted by adipocytes ,chemical structure of protein adiponectin contains 244 amino acids four domains , amino terminal peptide signal followed species _specific ,, collagen-like The variable space region 22 Gly-X-Y repeat, globular carboxbyb_ terminal domain binds to adiponectin receptor, which resembles complement factor C1q and a triangle-like topology for T.N.F levels of several adipokines (including adiponectin) leads to an increase in body weight and tends to act in a pro-inflammatory manner. On other hand, the concentration of adiponectin decreases in obese subjects. Adipokine works a suppress inflammation Processes,. Clinical research articles indicate low concentrations of adiponectin may be involved in the increase in obesity-related diseases, including cardiovascular disease, inflammation, and insulin resistance. current article concerned with influence of adiponectin protein at insulin resistance ,metabolic syndrome in patients with type 2 diabetes and comorbid disorders associated with obesity .
Downloads
Download data is not yet available.
References
1. A.H. Berg , P. E. Scherer .Adipose tissue, inflammation, and cardiovascular disease;96:939–49. [PubMed: 15890981] . 2005.
2. Q .Yang , ,T.E Graham N Mody, F .Preitner, O.D Peroni, J.M Zabolotny .Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature;436:356–62. . 2005.
3. S.H Song , C.H. Hardisty .Diagnosing Metabolic syndrome in Type 2 Diabeties: does it matter QJM; 101(6): 487-91. 2008
4. B .Falkner, S. Hassink, J Ross, S. Gidding,. Dysmetabolic syndrome: multiple risk factor premature adult disease in an adolescent girl. Pediatrics : 110(pt1) :e14. . 2002.
5. A .Maria, ,G Cardoso, W .Martins, L. Velarde. Prevalence of Metabolic Syndrome in Elderly and Agreement among Four Diagnostic Criteria ABC ; 102(3):263-69.1014 .
6. T.Kadowaki, T. Yamauchi, N. Kubota, ,K. Hara, K. Ueki, and K. Tobe. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. The Journal of Clinical Investigation .V.116 Nu. 7 .2006.
7. R . BANAEIFA, M. TAHERI, M. NORA, and L. IZADI, The effect of three months of aerobic training on serum levels of adiponectin and resistin in obese men. Report Health Care, 3 (1): 48-55, . 2017 .
8. W LAU, K. OHASHI, Y. WANG , H. OGAWA, T. MURO-HARA, X. MA. Role of adipokines in cardiovas-cular disease Circ. J., 81 (7): 920-928 . 2017.
9. H.N. Jung and C.H. Jung .The Role of anti-inflammatory adipokines in cardiometabolic disorders: Moving beyond adiponectin. Int. J. Mol. Sci., 22, 13529. 2021.
10. G. Wilcox.Insulin and Insulin Resistance. Clin. Bio-chem. Rev., 26 (2): 19-39, .2005 .
11. B. BRANDON B , J. R .CHRISTOPHER, and S. G. JOSEPH, The dynamic plasticity of insulin production in b-cells. Mol. Metab., 6 (9): 958-973 . 2017.
12. D .Maria, N. D Kalliope , and S. M Christos . Adiponectin and Cancer: A Review Endocrine Reviews, 33(4):547–594.2012.
13. H. Ruan and ,H.F Lodish. Insulin resistance in adipose tissue:direct and indirect effects of tumor necrosis factor-.Cytokine Growth Factor Rev 14:447–455. 2003.
14. F.M Fisher, M.E Trujillo ,W Hanif A.H Barnett, McTernan
15. P.G;Scherer, P.E and Kumar, S. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 48:1084–1087. 2005.
16. T.S Tsao, E Tomas, H.E Murrey, C Hug, D.H, Lee
17. N.B, Ruderman, J.E Heuser and Lodish, H.F..Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity.Different oligomers activate different signal transduction pathways. J Biol Chem 278:50810–50817.2003 .
18. M.F .Hivert,L.M Sullivan, C.S Fox, D. M .D gostino
19. , R.B. Sr, P. wilson W and Meigs, J,B. Associations of adiponectin, resistin, and tumor necrosis factor-_ with insulin resistance. J Clin Endocrinol Metab 93:3165–3172. 2008.
20. C .Weyer, T. Funahashi , S .Tanaka, K .Hotta , Y. Matsuzawa
21. R.E. Pratley and Tataranni ,P.A.Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930–1935. 2001 .
22. Hotta ,K;Funahashi ,T; Arita, Y; Takahashi, M;Matsuda,M, Okamoto,Y; Iwahashi ,H;Kuriyama ,H;Ouchi, N;Maeda,K,;Nishida, M, Kihara, S,;Sakai, N;Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita, S ; Hanafusa, T and Matsuzawa, Y ..Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2diabetic patients. Arterioscler Thromb Vasc Biol 20:1595– 1599.2000.
23. D. Barb , C. J .Williams , A. K. Neuwirth , C.S .Mantzoros .Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 86:s858–s866. 2007.
24. I. Kelesidis , T Kelesidis , C.S Mantzoros .Adiponectin
25. and cancer: a systematic review. Br J Cancer 94:1221–1225. 2006.
26. Mazaki-Tovi S, Romero, R; Vaisbuch, E; Erez O; Mittal, P, Chaiworapongsa T;Kim S.K; Pacora P; Yeo L, Gotsch F; Dong Z, Yoon B.H; Hassan, S.S; Kusanovic, J.P. Maternal serum adiponectin multimers in gestational diabetes . J Perinat Med 37:637–650.2009.
27. S Li, H.J Shin , E.L Ding and R.M . van Dam. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 302:179–188.2009.
28. M.B. Schulze , I. Shai , E.B .Rimm, T. Li , N Rifa and F.B. Hu . Adiponectin and future coronary heart disease events among men with type 2 diabetes. Diabetes 54:534–539.2015.
29. Y. Okamoto , Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, Ohashi K, Sakai N, Shimomura I, Kobayashi H, Terasaka N, Inaba T, Funa¬hashi T, Matsuzawa Y . Adiponectin reduces atherosclerosis in apoli¬poprotein E-deficient mice. Circulation;106:2767-2770.2020.
30. T . Omae , T. Nagaoka , I. Tanano , A. Yoshida .Adiponectin-induced dilation of isolated porcine retinal arterioles via production of nitric oxide from endothelial cells. Invest Ophthalmol Vis Sci;54:4586-4594. 2013.
31. T. Yamauchi , Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adi¬ponectin stimulates glucose utilization and fatty-acid oxidation by ac¬tivating AMP-activated protein kinase. Nat Med;8:1288-1295. 2002 .
32. T. Yamauchi , Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kad¬owaki T.. The fat-derived hormone adiponectin reverses insulin resis¬tance associated with both lipoatrophy and obesity. Nat Med;7:941-946. 2001.
33. F. Magkos and L.S. Sidossis .Recent advances in the measurement of adiponec¬tin isoform distribution. Curr Opin Clin Nutr Metab Care ;10:571-575. . 2007.
34. Y Cao, L .Tao ; Yuan ,Y; Jiao, X; Lau ,W.B; Wang, Y; Christopher T; Lopez, B; Chan, L; Goldstein B; Ma, X.L. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol ;46:413-419. 2009.
35. N .Ouchi , J.L Parker , J. J Lugus , Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11: 85–97. 2011.
36. T. Kadowaki and T . Yamauchi . Adiponectin and adiponectin receptors. Endocr Rev;26:439-451. 2005.
37. A. Hiuge-Shimizu, N. Maeda , A .Hirata , H. Nakatsuji , K. Nakamura, A .Okuno , S. Kihara and I. Shimomura . Dynamic changes of adi¬ponectin and S100A8 levels by the selective peroxisome prolifera¬tor-activated receptor-gamma agonist rivoglitazone. Arterioscler Thromb Vasc Biol ;31:792-799. 2011
38. K. Hotta . Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.Diabetes. 50:1126–1133. 2001.
39. 36., Y Arita . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257:79–83. 1999.
40. Y. Yamamoto, H . Hirose , I. Saito, K. Nishikai and T. Saruta. Adiponectin, an adipocytederived protein, predicts future insulin-resistance: two-year follow-up study in Japanese population.
41. T. Pischon. . Plasma adiponectin levels and risk of myocardial infarction in men. JAMA.
291:1730–1737. 2004.
42. T Yamauchi . The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med 7:941–946.2001.
43. J Fruebis . Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U. S. A.m98:2005–2010.
44. A.H Berg . The adipocyte-secreted protein
Han ,S.H; Quon ,M.J; Kim, J.A and Koh, K.K . Adiponectin and cardiovascular disease response to therapeutic interventions. J Am Coll Cardiol. ;49(5):531-8.2007.
45. Hopkins ,T.A;Ouchi, N; Shibata, R; Walsh ,K.. Adiponectin actions in the cardiovascular system. Cardiovasc Res.;74(1):11-8.2007.
46. Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M.. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2) and AMPK/SIRT1. Nature. ;464(7293):1313-9.2010.
47. Berg, A.H; Combs, TP; Du, X; Brownlee, M and Scherer ,P.E . The adipocyte-se¬creted protein Acrp30 enhances hepatic insulin action. Nat Med ;7:947-953.2001.
48. T.P. Combs , A.H. Bergm, S .Obici, P.E Scherer, L. Rossetti . Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest ;108:1875-1881.2001.
49. T .Kadowaki and T. Yamauchi. Adiponectin and adiponectin receptors, Endocr. Rev. 26 (2005) 439–451.2005.
50. T. Yamauchi, J. Kamon and Y. Minokoshi . Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase, Nat. Med. 8 .1288–1295.2002.
51. M Fasshauer, J. Klein and S. Kralisch. .Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes, FEBS Lett. 558 . 27–32.2004.
52. A. Yadav, M. A. Kataria, V.Saini, A.Yadav . Role of leptin and adiponectin in insulin resistance, Clin. Chim. Acta 417 80–84.2013.
53. R .VETTOR, G MILAN, , M. ROSSATO and FEDERSPIL. G. Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther 2005; 22 (Suppl. 2): 3–10.2005.
54. C.M. Steppan ,S.T Bailey and S. Bhat. The hormone resistin links obesity to diabetes. Nature ; 409: 307–12.2001.
55. A. Phillips and C. A .Cobbold. Comparison of the Effects of Aerobic and Intense Exercise on the Type 2 Diabetes Mellitus Risk Marker Adipokines, Adiponectin and Retinol Binding Protein-4. Int. J. Chronic Dis., 2014, 358058. 2014.
56. K.K Cheng, K.S Lam B.Wang, A. Xu .Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Pract. Res. Clin. Endocrinol. Metab., 28, 3–13. 2014.
57. L.A Elissa, N.M Elsherbiny and , A.O . Magmomah . Propolis restored adiponectin level in type 2 diabetes through PPAR activation. Egypt. J. Basic Appl. Sci., 2, 318–326. 2015.
58. M.K ,Hussain, F.A. Deli, A.H.A. Algenabi, K.H. Abdul-Rudha .Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population. Gene, 662, 118–122. 2018.
59. N. Siitonen , L. Pulkkinen, J. Lindstrom, M. Kolehmainen, J.G. Eriksson, M. Venojarvi, P. Ilanne-Parikka,
60. S. Keinänen- Kiukaanniemi, J. Tuomilehto, M Uusitupa ..Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: The Finnish Diabetes Prevention Study. BMC Med Genet., 12, 5. 2011.
61. V .Gupta, S. Mishra , S . Kumar and Gupta, V. Association of Leptin: Adiponectin ratio and metabolic risk markers in postmenopausal women. Immunol. Lett., 196, 63–67. 2018.
62. A. Yadav, M.A. Kataria, V .Saini, A. Yadav. Role of leptin and adiponectin in insulin resistance. Clin. Chim. Acta Int. J. Clin. Chem., 417, 80–84. 2013.
63. R.E Prates, M.V Beretta, F.V Nascimento, F.R Bernaud J.C. de Almeira, T.C. Rodrigues . Saturated fatty acid intake decreases serum adiponectin levels in subjects with type 1 diabetes. Diabetes Res. Clin. Pract., 116, 205–211 . 2016 .
2. Q .Yang , ,T.E Graham N Mody, F .Preitner, O.D Peroni, J.M Zabolotny .Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature;436:356–62. . 2005.
3. S.H Song , C.H. Hardisty .Diagnosing Metabolic syndrome in Type 2 Diabeties: does it matter QJM; 101(6): 487-91. 2008
4. B .Falkner, S. Hassink, J Ross, S. Gidding,. Dysmetabolic syndrome: multiple risk factor premature adult disease in an adolescent girl. Pediatrics : 110(pt1) :e14. . 2002.
5. A .Maria, ,G Cardoso, W .Martins, L. Velarde. Prevalence of Metabolic Syndrome in Elderly and Agreement among Four Diagnostic Criteria ABC ; 102(3):263-69.1014 .
6. T.Kadowaki, T. Yamauchi, N. Kubota, ,K. Hara, K. Ueki, and K. Tobe. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. The Journal of Clinical Investigation .V.116 Nu. 7 .2006.
7. R . BANAEIFA, M. TAHERI, M. NORA, and L. IZADI, The effect of three months of aerobic training on serum levels of adiponectin and resistin in obese men. Report Health Care, 3 (1): 48-55, . 2017 .
8. W LAU, K. OHASHI, Y. WANG , H. OGAWA, T. MURO-HARA, X. MA. Role of adipokines in cardiovas-cular disease Circ. J., 81 (7): 920-928 . 2017.
9. H.N. Jung and C.H. Jung .The Role of anti-inflammatory adipokines in cardiometabolic disorders: Moving beyond adiponectin. Int. J. Mol. Sci., 22, 13529. 2021.
10. G. Wilcox.Insulin and Insulin Resistance. Clin. Bio-chem. Rev., 26 (2): 19-39, .2005 .
11. B. BRANDON B , J. R .CHRISTOPHER, and S. G. JOSEPH, The dynamic plasticity of insulin production in b-cells. Mol. Metab., 6 (9): 958-973 . 2017.
12. D .Maria, N. D Kalliope , and S. M Christos . Adiponectin and Cancer: A Review Endocrine Reviews, 33(4):547–594.2012.
13. H. Ruan and ,H.F Lodish. Insulin resistance in adipose tissue:direct and indirect effects of tumor necrosis factor-.Cytokine Growth Factor Rev 14:447–455. 2003.
14. F.M Fisher, M.E Trujillo ,W Hanif A.H Barnett, McTernan
15. P.G;Scherer, P.E and Kumar, S. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 48:1084–1087. 2005.
16. T.S Tsao, E Tomas, H.E Murrey, C Hug, D.H, Lee
17. N.B, Ruderman, J.E Heuser and Lodish, H.F..Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity.Different oligomers activate different signal transduction pathways. J Biol Chem 278:50810–50817.2003 .
18. M.F .Hivert,L.M Sullivan, C.S Fox, D. M .D gostino
19. , R.B. Sr, P. wilson W and Meigs, J,B. Associations of adiponectin, resistin, and tumor necrosis factor-_ with insulin resistance. J Clin Endocrinol Metab 93:3165–3172. 2008.
20. C .Weyer, T. Funahashi , S .Tanaka, K .Hotta , Y. Matsuzawa
21. R.E. Pratley and Tataranni ,P.A.Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930–1935. 2001 .
22. Hotta ,K;Funahashi ,T; Arita, Y; Takahashi, M;Matsuda,M, Okamoto,Y; Iwahashi ,H;Kuriyama ,H;Ouchi, N;Maeda,K,;Nishida, M, Kihara, S,;Sakai, N;Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita, S ; Hanafusa, T and Matsuzawa, Y ..Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2diabetic patients. Arterioscler Thromb Vasc Biol 20:1595– 1599.2000.
23. D. Barb , C. J .Williams , A. K. Neuwirth , C.S .Mantzoros .Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 86:s858–s866. 2007.
24. I. Kelesidis , T Kelesidis , C.S Mantzoros .Adiponectin
25. and cancer: a systematic review. Br J Cancer 94:1221–1225. 2006.
26. Mazaki-Tovi S, Romero, R; Vaisbuch, E; Erez O; Mittal, P, Chaiworapongsa T;Kim S.K; Pacora P; Yeo L, Gotsch F; Dong Z, Yoon B.H; Hassan, S.S; Kusanovic, J.P. Maternal serum adiponectin multimers in gestational diabetes . J Perinat Med 37:637–650.2009.
27. S Li, H.J Shin , E.L Ding and R.M . van Dam. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 302:179–188.2009.
28. M.B. Schulze , I. Shai , E.B .Rimm, T. Li , N Rifa and F.B. Hu . Adiponectin and future coronary heart disease events among men with type 2 diabetes. Diabetes 54:534–539.2015.
29. Y. Okamoto , Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, Ohashi K, Sakai N, Shimomura I, Kobayashi H, Terasaka N, Inaba T, Funa¬hashi T, Matsuzawa Y . Adiponectin reduces atherosclerosis in apoli¬poprotein E-deficient mice. Circulation;106:2767-2770.2020.
30. T . Omae , T. Nagaoka , I. Tanano , A. Yoshida .Adiponectin-induced dilation of isolated porcine retinal arterioles via production of nitric oxide from endothelial cells. Invest Ophthalmol Vis Sci;54:4586-4594. 2013.
31. T. Yamauchi , Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adi¬ponectin stimulates glucose utilization and fatty-acid oxidation by ac¬tivating AMP-activated protein kinase. Nat Med;8:1288-1295. 2002 .
32. T. Yamauchi , Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kad¬owaki T.. The fat-derived hormone adiponectin reverses insulin resis¬tance associated with both lipoatrophy and obesity. Nat Med;7:941-946. 2001.
33. F. Magkos and L.S. Sidossis .Recent advances in the measurement of adiponec¬tin isoform distribution. Curr Opin Clin Nutr Metab Care ;10:571-575. . 2007.
34. Y Cao, L .Tao ; Yuan ,Y; Jiao, X; Lau ,W.B; Wang, Y; Christopher T; Lopez, B; Chan, L; Goldstein B; Ma, X.L. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol ;46:413-419. 2009.
35. N .Ouchi , J.L Parker , J. J Lugus , Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11: 85–97. 2011.
36. T. Kadowaki and T . Yamauchi . Adiponectin and adiponectin receptors. Endocr Rev;26:439-451. 2005.
37. A. Hiuge-Shimizu, N. Maeda , A .Hirata , H. Nakatsuji , K. Nakamura, A .Okuno , S. Kihara and I. Shimomura . Dynamic changes of adi¬ponectin and S100A8 levels by the selective peroxisome prolifera¬tor-activated receptor-gamma agonist rivoglitazone. Arterioscler Thromb Vasc Biol ;31:792-799. 2011
38. K. Hotta . Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.Diabetes. 50:1126–1133. 2001.
39. 36., Y Arita . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257:79–83. 1999.
40. Y. Yamamoto, H . Hirose , I. Saito, K. Nishikai and T. Saruta. Adiponectin, an adipocytederived protein, predicts future insulin-resistance: two-year follow-up study in Japanese population.
41. T. Pischon. . Plasma adiponectin levels and risk of myocardial infarction in men. JAMA.
291:1730–1737. 2004.
42. T Yamauchi . The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med 7:941–946.2001.
43. J Fruebis . Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U. S. A.m98:2005–2010.
44. A.H Berg . The adipocyte-secreted protein
Han ,S.H; Quon ,M.J; Kim, J.A and Koh, K.K . Adiponectin and cardiovascular disease response to therapeutic interventions. J Am Coll Cardiol. ;49(5):531-8.2007.
45. Hopkins ,T.A;Ouchi, N; Shibata, R; Walsh ,K.. Adiponectin actions in the cardiovascular system. Cardiovasc Res.;74(1):11-8.2007.
46. Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M.. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2) and AMPK/SIRT1. Nature. ;464(7293):1313-9.2010.
47. Berg, A.H; Combs, TP; Du, X; Brownlee, M and Scherer ,P.E . The adipocyte-se¬creted protein Acrp30 enhances hepatic insulin action. Nat Med ;7:947-953.2001.
48. T.P. Combs , A.H. Bergm, S .Obici, P.E Scherer, L. Rossetti . Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest ;108:1875-1881.2001.
49. T .Kadowaki and T. Yamauchi. Adiponectin and adiponectin receptors, Endocr. Rev. 26 (2005) 439–451.2005.
50. T. Yamauchi, J. Kamon and Y. Minokoshi . Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase, Nat. Med. 8 .1288–1295.2002.
51. M Fasshauer, J. Klein and S. Kralisch. .Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes, FEBS Lett. 558 . 27–32.2004.
52. A. Yadav, M. A. Kataria, V.Saini, A.Yadav . Role of leptin and adiponectin in insulin resistance, Clin. Chim. Acta 417 80–84.2013.
53. R .VETTOR, G MILAN, , M. ROSSATO and FEDERSPIL. G. Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther 2005; 22 (Suppl. 2): 3–10.2005.
54. C.M. Steppan ,S.T Bailey and S. Bhat. The hormone resistin links obesity to diabetes. Nature ; 409: 307–12.2001.
55. A. Phillips and C. A .Cobbold. Comparison of the Effects of Aerobic and Intense Exercise on the Type 2 Diabetes Mellitus Risk Marker Adipokines, Adiponectin and Retinol Binding Protein-4. Int. J. Chronic Dis., 2014, 358058. 2014.
56. K.K Cheng, K.S Lam B.Wang, A. Xu .Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Pract. Res. Clin. Endocrinol. Metab., 28, 3–13. 2014.
57. L.A Elissa, N.M Elsherbiny and , A.O . Magmomah . Propolis restored adiponectin level in type 2 diabetes through PPAR activation. Egypt. J. Basic Appl. Sci., 2, 318–326. 2015.
58. M.K ,Hussain, F.A. Deli, A.H.A. Algenabi, K.H. Abdul-Rudha .Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population. Gene, 662, 118–122. 2018.
59. N. Siitonen , L. Pulkkinen, J. Lindstrom, M. Kolehmainen, J.G. Eriksson, M. Venojarvi, P. Ilanne-Parikka,
60. S. Keinänen- Kiukaanniemi, J. Tuomilehto, M Uusitupa ..Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: The Finnish Diabetes Prevention Study. BMC Med Genet., 12, 5. 2011.
61. V .Gupta, S. Mishra , S . Kumar and Gupta, V. Association of Leptin: Adiponectin ratio and metabolic risk markers in postmenopausal women. Immunol. Lett., 196, 63–67. 2018.
62. A. Yadav, M.A. Kataria, V .Saini, A. Yadav. Role of leptin and adiponectin in insulin resistance. Clin. Chim. Acta Int. J. Clin. Chem., 417, 80–84. 2013.
63. R.E Prates, M.V Beretta, F.V Nascimento, F.R Bernaud J.C. de Almeira, T.C. Rodrigues . Saturated fatty acid intake decreases serum adiponectin levels in subjects with type 1 diabetes. Diabetes Res. Clin. Pract., 116, 205–211 . 2016 .
Published
2024-06-28
How to Cite
Alsaadi, J. H. H., & M.Younis, H. (2024). Bioactive of Adiponectin in Metabolic Diseases a Review Article. Central Asian Journal of Theoretical and Applied Science, 5(3), 132-142. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1466
Issue
Section
Articles
Copyright (c) 2024 Central Asian Journal of Theoretical and Applied Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
