Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking

Farah M.  Muhammad; Bushra A.  Khairallah; Mohammed Jwher  Saleh; Jamil Nadhem  Saleh

Farah M. Muhammad Department of Chemistry, College of Education for Pure Sciences, Tikrit University, Iraq
Bushra A. Khairallah Department of Chemistry, College of Education for Pure Sciences, Tikrit University, Iraq
Mohammed Jwher Saleh Salah Al-Din Education Directorate, Iraq
Jamil Nadhem Saleh Salah Al-Din Education Directorate, Iraq

Keywords: Heterocyclic, Oxazine, biological activity, Molecular docking, laser

Abstract

The study included the preparation of new hexagonal rings by reacting the prepared chalcone with urea by sublimation and verifying the validity of the prepared structures using physical measurements such as color and melting point. For example, infrared spectroscopy, proton, and carbon NMR spectroscopy were also tested for bioavailability against two types of Gram- positive and Gram-negative bacteria Using MOE software (2009), the molecular docking of a few produced drugs against E. coli was investigated. The laser activity of some of the prepared compounds was measured using a helium-neon laser device (visible laser), where each compound irradiated the prepared compounds for four times (15, 30, 45, 60) seconds.

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