Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy
Keywords:
Imidazole, Laser, Biological Activity.
Abstract
This research aims to synthesize and characterize imidazole derivatives from the reaction of hydrazones with amino acids (glycine and alanine) using conventional methods. The validity of the synthesized compounds was confirmed through physical measurements such as melting point and color, as well as spectroscopic methods such as infrared spectroscopy and proton nuclear magnetic resonance spectroscopy. The research methods included testing the biological effectiveness of the compounds against two types of bacteria: Gram-positive Staphylococcus epidermidis and Gram-negative Klebsiella pneumoniae. The compounds (M11-M15) were also irradiated using a neodymium nanosecond laser system (Nd laser) with a wavelength of 808 nm and a frequency of 5 Hz. Changes in melting point and color were measured after irradiation. The results showed that the synthesized compounds exhibited significant antibacterial activity against both types of bacteria. Additionally, some compounds demonstrated high stability under laser irradiation, while others experienced changes in melting point and color, indicating alterations in bond structures.
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References
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24. Zhang, L., Peng, X. M., Damu, G. L., Geng, R. X., & Zhou, C. H. (2014). Comprehensive review of current developments of imidazole‐based medicinal chemistry. Medicinal research reviews, 34(2), 340-437.
2. Al Rashidy, A. A. M., Al Badrany, K. A., & Al Garagoly, G. M. (2020, August). Spectrophotometric determination of sulphamethoxazole drug by new pyrazoline derived from 2, 4-dinitro phenyl hydrazine. In Materials Science Forum (Vol. 1002, pp. 350-359). Trans Tech Publications Ltd.
3. Al-Badrany, K. A., Mohammed, A. S., & Alasadi, Y. K. (2019). Synthesis of some new 1, 3, 4-oxadiazole compounds derived from 1H-imidazole and study their biological activity. Eurasian Journal of Biosciences, 13(1), 501-507.
4. Al-Jubori, H. M. S. (2024). Preparation and Characterization of Some 1, 3-Oxazepane-7, 4-Dione Derivatives and Evaluation of their Biological Activity. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 333-343.
5. Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
6. Andrei, G. Ş., Andrei, B. F., & Roxana, P. R. (2021). Imidazole derivatives and their antibacterial activity-a mini-review. Mini-Reviews in Medicinal Chemistry, 21(11), 1380-1392.
7. Awasthi, A., Rahman, M. A., & Bhagavan Raju, M. (2023). Synthesis, in silico studies, and in vitro anti-inflammatory activity of novel imidazole derivatives targeting P38 MAP kinase. ACS omega, 8(20), 17788-17799.
8. Dalaf, A. H., Jumaa, F. H., Aftana, M. M., Salih, H. K., & Abd, I. Q. (2022). Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole. In Key Engineering Materials (Vol. 911, pp. 33-39). Trans Tech Publications Ltd.
9. Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 155-168.
10. Daraji, D. G., Prajapati, N. P., & Patel, H. D. (2019). Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review. Journal of Heterocyclic Chemistry, 56(9), 2299-2317.
11. Fan, Y. L., Jin, X. H., Huang, Z. P., Yu, H. F., Zeng, Z. G., Gao, T., & Feng, L. S. (2018). Recent advances of imidazole-containing derivatives as anti-tubercular agents. European journal of medicinal chemistry, 150, 347-365.
12. Gaba, M., & Mohan, C. (2016). Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions. Medicinal Chemistry Research, 25, 173-210.
13. Ma, B., Zhang, J., Mi, Y., Miao, Q., Tan, W., & Guo, Z. (2023). Preparation of imidazole acids grafted chitosan with enhanced antioxidant, antibacterial and antitumor activities. Carbohydrate Polymers, 315, 120978.
14. Mishra, R., & GangJuly, S. (2012). Imidazole as an anti-epileptic: an overview. Medicinal Chemistry Research, 21, 3929-3939.
15. Mohamed, S. A., Hussein, M. S., & Al-badrany, K. A. (2022). Synthesis and characterization of pyrazolines and oxazapine derivatives using chalcones as precursor and evaluation of their biological activity. Samarra Journal of Pure and Applied Science, 4(4).
16. Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
17. Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
18. Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
19. Saleh, R. H., Rashid, W. M., Dalaf, A. H., Al-Badrany, K. A., & Mohammed, O. A. (2020). Synthesis of some new thiazolidinone compounds derived from schiff bases compounds and evaluation of their laser and biological efficacy. Ann Trop & Public Health, 23(7), 1012-1031.
20. Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
21. Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
22. Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
23. Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.
24. Zhang, L., Peng, X. M., Damu, G. L., Geng, R. X., & Zhou, C. H. (2014). Comprehensive review of current developments of imidazole‐based medicinal chemistry. Medicinal research reviews, 34(2), 340-437.
Published
2024-07-27
How to Cite
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1474
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Articles
