Preparation and Characterization of Tetrazole Derivatives Derived from Schiff Bases and Evaluation of Biological Activity
Keywords:
Heterocyclic, Tetrazole, Biological Activity
Abstract
This study included the preparation of heterogeneous pentagonal rings derived from tetrazole ring by reacting Schiff's radicals derived from 6-methyl-2-uracil and using them as nuclei in the preparation with sodium azide using tetrahydrofuran solvent. The compounds were confirmed using physical measurements such as color, melting point, and product percentage. Spectroscopic measurements, such as the infrared spectrum and nuclear magnetic resonance spectrum, were also used to determine the composition of the compound. The effectiveness of some of these compounds was also tested against two types of Gram-positive and Gram-negative bacteria using amoxicillin as an antibiotic.
Downloads
Download data is not yet available.
References
1. Abdul Wahed, A. S. T. (2024). Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1, 3-Oxazepine-4, 7-Dione Derivatives. Central Asian Journal of Theoretical and Applied Sciences, 5(2), 15-26.
2. Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
3. Alasadi, Y. K., Jumaa, F. H., Dalaf, A. H., Shawkat, S. M., & Mukhlif, M. G. (2022). Synthesis, Characterization, and Molecular Docking of New Tetrazole Derivatives as Promising Anticancer Agents. Journal of Pharmaceutical Negative Results, 13(3), 513-522.
4. Al-Badraani, K. A., & Al-Juboori, I. K. (2007). Synthesis of some new-2-Amino-6-substituted benzonthiazole and there Shiff bases. Surra Man Ra'a, 3(6).
5. AL-Garagoly, G. M., AL-Rashidy, A. A., & AL-Badrany, K. A. (2019). Spectrophotometric Determination of Sulfanilamide in Pure and Synthetic Sample by New Derivative from Pyrazoline Derived from 2, 4-Dinitro Phenyl Hydrazine. Diyala Journal for Pure Science, 15(4).
6. Aljobory, A. A. K., & Albadrany, K. A. A. A. (2020). Synthesis of some pyrmidin compounds derived from chalcon and evaluation their biological activity. Samarra Journal of Pure and Applied Science, 2(2).
7. Al-jobury, I., S Mohammed, A., & A Al-badrany, K. (2016). Synthesis of some new Pyrazoline derivatives derived from Ibuprofen. Kirkuk Journal of Science, 11(3), 254-262.
8. Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). Green Synthesis, Characterization, And Multifaceted Evaluation Of Thiazolidinone Derivatives: A Study On Biological And Laser Efficacy. European Journal of Modern Medicine and Practice, 4(7), 155-168.
9. Ibrahim, O. M., & Jumaa, F. H. (2024). Synthesis, Characterization, And Evaluation Of Bacterial Activity And Liquid Crystal Properties Of New Derivatives Of Tetrazole Compounds Using Triethyl Benzene-1, 3, 5-Tricarboxylate As A Starting Material. European Journal Of Modern Medicine And Practice, 4(6), 448-458.
10. Kabi, A. K., Sravani, S., Gujjarappa, R., Garg, A., Vodnala, N., Tyagi, U., ... & Malakar, C. C. (2022). An overview on biological evaluation of tetrazole derivatives. Nanostructured Biomaterials: Basic Structures and Applications, 307-349.
11. Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
12. Łukowska-Chojnacka, E., Kowalkowska, A., Gizińska, M., Koronkiewicz, M., & Staniszewska, M. (2019). Synthesis of tetrazole derivatives bearing pyrrolidine scaffold and evaluation of their antifungal activity against Candida albicans. European journal of medicinal chemistry, 164, 106-120.
13. Mahmoud Mehdi Saleh, Jamil Nadhem Saleh, Fahad Farhan Rokan, & Mohammed Jwher Saleh. (2024). Synthesis,Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex[Co (2-(benzo[d]thiazol-2-yloxy) acetohydrazide) (H2O) (Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4), 198 -.
14. Mekheimer, R. A., Abuo-Rahma, G. E. D. A., Abd-Elmonem, M., Yahia, R., Hisham, M., Hayallah, A. M., ... & Sadek, K. U. (2022). New s-Triazine/Tetrazole conjugates as potent antifungal and antibacterial agents: Design, molecular docking and mechanistic study. Journal of Molecular Structure, 1267, 133615.
15. Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138.
16. Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
17. Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
18. Owed, A.I., Al – Jubouri, A.A., & Al-Samarrai, S.Y. (2024). A nano-sensor for copper oxide was manufactured and developed using a new organic precipitant via green chemistry methods. Sensors and Machine Learning Applications.
19. Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
20. Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
21. Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). Preparation, Characterization, And Evaluation Of The Biological Activity Of Pyrazoline Derivatives Prepared Using A Solid Base Catalyst. European Journal Of Modern Medicine And Practice, 4(7), 25-32.
22. Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
23. Shannak, M. Q. A., Othman, I. A. W., Rasheed, M. K., & Mahmood, S. K. (2018). Synthesis and Characterization of New Some Binuclear Complexes for Some Transition Element Metals with Schiff Base ligand Derived from 1-Chloro-2-(2-Chloroethoxy) Ethane. Eurasian Journal of Analytical Chemistry, 13, 339-346.
24. Shannak, Q. A. (2020). Characteristic Studying and Biological Effect of Synthesized Complexes Pd (II) and Hg (II) with Uracil dithiocarbamate and Phosphine’s. Systematic Reviews in Pharmacy, 11(3), 693-701.
25. Shannak, Q. A., Najim, T. M., & Madab, D. I. (2022). Evaluation of the level of vitamin D3 in the blood serum of patients infected with COVID-19 in Al-Amiriya city. Technium BioChemMed, 3(2), 127-135.
26. Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
27. Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
28. Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation, and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
29. Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., & Al-Jubori, H. M. S. (2024). Synthesis and Characterization of Some New Imine Graphene Derivatives and Evaluation of Their Biological Activity. Central Asian Journal of Medical and Natural Science, 5(4), 272-290.
30. Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. European Journal Of Modern Medicine And Practice, 4(4), 326-332.
2. Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
3. Alasadi, Y. K., Jumaa, F. H., Dalaf, A. H., Shawkat, S. M., & Mukhlif, M. G. (2022). Synthesis, Characterization, and Molecular Docking of New Tetrazole Derivatives as Promising Anticancer Agents. Journal of Pharmaceutical Negative Results, 13(3), 513-522.
4. Al-Badraani, K. A., & Al-Juboori, I. K. (2007). Synthesis of some new-2-Amino-6-substituted benzonthiazole and there Shiff bases. Surra Man Ra'a, 3(6).
5. AL-Garagoly, G. M., AL-Rashidy, A. A., & AL-Badrany, K. A. (2019). Spectrophotometric Determination of Sulfanilamide in Pure and Synthetic Sample by New Derivative from Pyrazoline Derived from 2, 4-Dinitro Phenyl Hydrazine. Diyala Journal for Pure Science, 15(4).
6. Aljobory, A. A. K., & Albadrany, K. A. A. A. (2020). Synthesis of some pyrmidin compounds derived from chalcon and evaluation their biological activity. Samarra Journal of Pure and Applied Science, 2(2).
7. Al-jobury, I., S Mohammed, A., & A Al-badrany, K. (2016). Synthesis of some new Pyrazoline derivatives derived from Ibuprofen. Kirkuk Journal of Science, 11(3), 254-262.
8. Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). Green Synthesis, Characterization, And Multifaceted Evaluation Of Thiazolidinone Derivatives: A Study On Biological And Laser Efficacy. European Journal of Modern Medicine and Practice, 4(7), 155-168.
9. Ibrahim, O. M., & Jumaa, F. H. (2024). Synthesis, Characterization, And Evaluation Of Bacterial Activity And Liquid Crystal Properties Of New Derivatives Of Tetrazole Compounds Using Triethyl Benzene-1, 3, 5-Tricarboxylate As A Starting Material. European Journal Of Modern Medicine And Practice, 4(6), 448-458.
10. Kabi, A. K., Sravani, S., Gujjarappa, R., Garg, A., Vodnala, N., Tyagi, U., ... & Malakar, C. C. (2022). An overview on biological evaluation of tetrazole derivatives. Nanostructured Biomaterials: Basic Structures and Applications, 307-349.
11. Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
12. Łukowska-Chojnacka, E., Kowalkowska, A., Gizińska, M., Koronkiewicz, M., & Staniszewska, M. (2019). Synthesis of tetrazole derivatives bearing pyrrolidine scaffold and evaluation of their antifungal activity against Candida albicans. European journal of medicinal chemistry, 164, 106-120.
13. Mahmoud Mehdi Saleh, Jamil Nadhem Saleh, Fahad Farhan Rokan, & Mohammed Jwher Saleh. (2024). Synthesis,Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex[Co (2-(benzo[d]thiazol-2-yloxy) acetohydrazide) (H2O) (Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4), 198 -.
14. Mekheimer, R. A., Abuo-Rahma, G. E. D. A., Abd-Elmonem, M., Yahia, R., Hisham, M., Hayallah, A. M., ... & Sadek, K. U. (2022). New s-Triazine/Tetrazole conjugates as potent antifungal and antibacterial agents: Design, molecular docking and mechanistic study. Journal of Molecular Structure, 1267, 133615.
15. Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138.
16. Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
17. Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
18. Owed, A.I., Al – Jubouri, A.A., & Al-Samarrai, S.Y. (2024). A nano-sensor for copper oxide was manufactured and developed using a new organic precipitant via green chemistry methods. Sensors and Machine Learning Applications.
19. Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
20. Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
21. Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). Preparation, Characterization, And Evaluation Of The Biological Activity Of Pyrazoline Derivatives Prepared Using A Solid Base Catalyst. European Journal Of Modern Medicine And Practice, 4(7), 25-32.
22. Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
23. Shannak, M. Q. A., Othman, I. A. W., Rasheed, M. K., & Mahmood, S. K. (2018). Synthesis and Characterization of New Some Binuclear Complexes for Some Transition Element Metals with Schiff Base ligand Derived from 1-Chloro-2-(2-Chloroethoxy) Ethane. Eurasian Journal of Analytical Chemistry, 13, 339-346.
24. Shannak, Q. A. (2020). Characteristic Studying and Biological Effect of Synthesized Complexes Pd (II) and Hg (II) with Uracil dithiocarbamate and Phosphine’s. Systematic Reviews in Pharmacy, 11(3), 693-701.
25. Shannak, Q. A., Najim, T. M., & Madab, D. I. (2022). Evaluation of the level of vitamin D3 in the blood serum of patients infected with COVID-19 in Al-Amiriya city. Technium BioChemMed, 3(2), 127-135.
26. Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
27. Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
28. Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation, and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
29. Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., & Al-Jubori, H. M. S. (2024). Synthesis and Characterization of Some New Imine Graphene Derivatives and Evaluation of Their Biological Activity. Central Asian Journal of Medical and Natural Science, 5(4), 272-290.
30. Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. European Journal Of Modern Medicine And Practice, 4(4), 326-332.
Published
2024-07-27
How to Cite
Khalaf, M. ziadan. (2024). Preparation and Characterization of Tetrazole Derivatives Derived from Schiff Bases and Evaluation of Biological Activity. Central Asian Journal of Theoretical and Applied Science, 5(4), 356-363. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1487
Section
Articles
