Study of the Effect of Proteus Mirabilis Bactria on the Kidney Tissue of Laboratory Mice

Wurood Faisal  Kareem; Manar Safaa Jasim  Mohamed; Fatima Hachim  Sultan; Zeina Ibrahim  Khalil

Wurood Faisal Kareem Department of Pathological Analyses, College of Applied Sciences, University of Samarra, Iraq
Manar Safaa Jasim Mohamed Department of Pathological Analyses, College of Applied Sciences, University of Samarra, Iraq
Fatima Hachim Sultan Department of Pathological Analyses, College of Applied Sciences, University of Samarra, Iraq
Zeina Ibrahim Khalil Department of Pathological Analyses, College of Applied Sciences, University of Samarra, Iraq

Keywords: Proteus mirabilis, Kidney tissue, Laboratory mice, Urinary tract infection, Opportunistic bacteria

Abstract

This study aimed to investigate the effects of Proteus mirabilis on the kidney tissues of laboratory mice. A total of 30 urine samples were collected from female patients with urinary tract infections. The presence of Proteus mirabilis was confirmed through bacteriological tests. Mice were orally dosed with P. mirabilis over two weeks, and their kidneys were later examined for pathological changes. Histological analysis revealed various stages of degeneration, lymphocyte infiltration, and glomerular damage. The study concluded that P. mirabilis induces significant kidney tissue damage, including necrosis, hemorrhage, and congestion, particularly at higher bacterial concentrations.

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