Synthesis, Characterization & Biological Survey of Novel 1,2,4-Triazole Schiff Base Derivatives

Zuhair M.  Hassoon; Israa A.  Alkhayyat; Ahmed M. I.  Alsanafi; Ibrahim A.  Flifel

Zuhair M. Hassoon Directorate of Education in Thi-Qar, Ministry of Education, Iraq
Israa A. Alkhayyat Department of Chemistry, College of Science, Thi-Qar University, Iraq
Ahmed M. I. Alsanafi Directorate of Education in Thi-Qar, Ministry of Education, Iraq
Ibrahim A. Flifel Department of Chemistry, College of Science, Thi-Qar University, Iraq

Keywords: heterocyclic, triazole, antibacterial, ligand, complex, properties, electrostatic

Abstract

In the present study, a new ligand, 4-{[(1E)-1-(2-hydroxy-5-methyl-3 nitrophenyl) ethylidene]amino}-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (L) and synthesis of iron (III), copper (II) and red copper (III) complexes. By using techniques including FT-IR, 1H-NMR, mass, molar conductivity, and magnetic susceptibility, the ligand and its complexes were verified to be real. Researchers looked into the compounds' antibacterial activities against the Gram-positive and Gram-negative bacterial strains of Staphylococcus aureus and Pseudomonas aeruginosa. The ligand's bioavailability investigations and its complexes showed good results compared to a standard antibiotic (ampicillin). Theoretical calculations were performed using the Hyperchem program and the electrostatic potential was studied using a semiempirical approach, which provided good information about the location of the complex. In addition, the stabilization energies of the complexes were studied. Based on the magnetic susceptibility and molar conductivity results, for the Cr(III) and Fe(III) complexes, we suggest an octahedral geometry, and for the Cu(II) complex, a tetrahedral geometry.

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