Synthesis and Characterization of New Derivatives of 2,3-Dihydroquinazolin-4-one and Evaluation of their Antibacterial Activity
Keywords:
Hydrazones, 2,3-Dihydroquinazolin-4-one, Biological activity
Abstract
The present study included the synthesis of heterogeneous compounds of hydroquinazoline by reacting the prepared hydrazones with 2-aminophenol in the presence of ethanol as a solvent. The structures of the formed compounds were confirmed by physical and spectroscopic methods such as infrared spectra and proton and carbon nuclear magnetic resonance spectra (1H, 13C-NMR). The biological activity was evaluated using two types of bacterial isolates known for their resistance to antibiotics, namely Gram-negative Escherichia coli (Gram -ve) and Gram-positive Staphylococcus aureus (Gram +ve), and compared with the antibiotic as a control factor (Controls) Ciprofloxacin. The results showed good inhibitory activity for two types of used bacteria and high effectiveness and selectivity.
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References
Abdul Wahed, A. S. T. (2024). Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1, 3-Oxazepine-4, 7-Dione Derivatives. Central Asian Journal of Theoretical and Applied Sciences, 5(2), 15-26.
Aftan, M. M., Salih, H. K., & Talloh, A. A. (2021). Synthesis of new mesogenic Schiff bases ether with polar halogen Substituent and study their liquid crystalline properties. Journal of Education and Scientific Studies, 5(17).
Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
Al Rashidy, A. A. M., Al Badrany, K. A., & Al Garagoly, G. M. (2020, August). Spectrophotometric determination of sulphamethoxazole drug by new pyrazoline derived from 2, 4-dinitro phenyl hydrazine. In Materials Science Forum (Vol. 1002, pp. 350-359). Trans Tech Publications Ltd.
Al-Joboury, N. A., Al-Badrany, K. A., Hamed, A. S., & Aljoboury, W. M. (2019). SYNTHESIS OF SOME NEW THIAZEPINE COMPOUNDS DERIVED FROM CHALCONES AND EVALUATION THERE BIOCHEMICAL AND BIOLOGICAL ACTIVITY. Biochemical & Cellular Archives, 19(2).
Al-badrany, K. A., Al-jobury, A. I., & Mohammed, A. S. Synthesis of some new Pyrazoline derivatives derived from Ibuprofen.
Asmaa Ahmed Mohammed Alrashidy, Omar Adnan Hashem, Kalid Abdul-Aziz ALBadrany. (2024). Spectrophotometric Determination of Vitamin C Using Indirect Oxidation with a New Organic Dye, Journal of Angiotherpay, 8(2), 1-7, 9499
Atukuri, D., & Mujavar, P. H. (2022). Recent update on the pharmacological significance of Isatis tinctoria L.(Brassicaceae) extracts. Polycyclic Aromatic Compounds, 42(7), 4843-4861.
Bhat, M., Belagali, S. L., Mamatha, S. V., Sagar, B. K., & Sekhar, E. V. (2021). Importance of quinazoline and quinazolinone derivatives in medicinal chemistry. Studies in Natural Products Chemistry, 71, 185-219.
Dalaf, A. H., Jumaa, F. H., & Jabbar, S. A. S. (2018). Synthesis and Characterization of some 2, 3-dihydroquinozoline and evaluation of their biological activity. Red, 38, 632-68.
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. European Journal of Modern Medicine and Practice, 4(7), 155-168.
Farah M. Muhammad, Bushra A. Khairallah, K. A. Albadrany. (2024). Synthesis, characterization and Antibacterial Evaluation of Novel 1,3-Oxazepine Derivatives Using A Cycloaddition Approach, Journal of Angiotherapy, 8(3), 1-9, 9506
Faraj, E. M., & Jumaa, F. H. (2022). Preparation, diagnostics and biological evaluation of new Schiff base and tetrazole derivatives. Materials Today: Proceedings, 49, 3549-3557.
Jumaa, F. H. (2018). Preparation, Identification and study Antibacterial Activity of Some new 2, 3-Dihydroquinazolin-4 (1H)-one Derivatives. Tikrit Journal of Pure Science, 23(9), 51-60.
Jumaa, F. H., Yass, I. A., & Ibrahim, B. K. (2023). Synthesis, Study of Their Liquid Crystal, Laser Properties of New Binary 1, 3-Oxazepine-4, 7-dione Derivatives and Evaluation of the Antibacterial Activity of Some of Them. Journal of Global Scientific Research, 8(9), 3201-3214.
Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
Magesh, M., Keerthika, B., Bharathi, D., Premavathi, K., Vijayalakshmi, M. K., & Lavanya, M. (2023). Overview of the Biological Activities of Quinazolines. Journal of Coastal Life Medicine, 11, 1879-1887.
Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
NAJM, R. S. (2019). Synthesis and biological activity evaluation of some new pyrazole derivatives. International Journal of Pharmaceutical Research, 11(1).
Owed, A. I., Al-Jubouri, A. A., & Al-Samarrai, S. Y. (2024). A nano-sensor for copper oxide was manufactured and developed using a new organic precipitant via green chemistry methods. Sensors and Machine Learning Applications, 1(1).
Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
Saleh, M. M., Saleh, J. N., Rokan, F. F., & Saleh, M. J. (2024). Synthesis, Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex [Co (2-(benzo [d] thiazol-2-yloxy) acetohydrazide)(H2O)(Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4).
Saleh, M. M. Amenah l. Al-Nassiry, Jamil Nadhem Saleh, & Mohammed Jwher Saleh.(2024). Preparation and Diagnosis of New Complexes for Hg (II) With 4-Amino Acetanilide And (Dppp) As A Ligand And Study Of The Bacterial Efficacy And Molecular Docking Of The Prepared Complexes. Central Asian Journal of Theoretical and Applied Science, 5(4), 364-373.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., & Al-Jubori, H. M. S. (2024). Synthesis and Characterization of Some New Imine Graphene Derivatives and Evaluation of Their Biological Activity. Central Asian Journal of Medical and Natural Science, 5(4), 272-290.
Talluh, A. W. A. S., Najm, R. S., Saleh, M. J., & Saleh, J. N. (2024). Synthesis, Characterization, and Evaluation of the Biological Activity of Novel Oxazepine Compounds Derived From Indole-5-Carboxylic Acid. American Journal of Bioscience and Clinical Integrity, 1(8), 10-19.
Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.
Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
Aftan, M. M., Salih, H. K., & Talloh, A. A. (2021). Synthesis of new mesogenic Schiff bases ether with polar halogen Substituent and study their liquid crystalline properties. Journal of Education and Scientific Studies, 5(17).
Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
Al Rashidy, A. A. M., Al Badrany, K. A., & Al Garagoly, G. M. (2020, August). Spectrophotometric determination of sulphamethoxazole drug by new pyrazoline derived from 2, 4-dinitro phenyl hydrazine. In Materials Science Forum (Vol. 1002, pp. 350-359). Trans Tech Publications Ltd.
Al-Joboury, N. A., Al-Badrany, K. A., Hamed, A. S., & Aljoboury, W. M. (2019). SYNTHESIS OF SOME NEW THIAZEPINE COMPOUNDS DERIVED FROM CHALCONES AND EVALUATION THERE BIOCHEMICAL AND BIOLOGICAL ACTIVITY. Biochemical & Cellular Archives, 19(2).
Al-badrany, K. A., Al-jobury, A. I., & Mohammed, A. S. Synthesis of some new Pyrazoline derivatives derived from Ibuprofen.
Asmaa Ahmed Mohammed Alrashidy, Omar Adnan Hashem, Kalid Abdul-Aziz ALBadrany. (2024). Spectrophotometric Determination of Vitamin C Using Indirect Oxidation with a New Organic Dye, Journal of Angiotherpay, 8(2), 1-7, 9499
Atukuri, D., & Mujavar, P. H. (2022). Recent update on the pharmacological significance of Isatis tinctoria L.(Brassicaceae) extracts. Polycyclic Aromatic Compounds, 42(7), 4843-4861.
Bhat, M., Belagali, S. L., Mamatha, S. V., Sagar, B. K., & Sekhar, E. V. (2021). Importance of quinazoline and quinazolinone derivatives in medicinal chemistry. Studies in Natural Products Chemistry, 71, 185-219.
Dalaf, A. H., Jumaa, F. H., & Jabbar, S. A. S. (2018). Synthesis and Characterization of some 2, 3-dihydroquinozoline and evaluation of their biological activity. Red, 38, 632-68.
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. European Journal of Modern Medicine and Practice, 4(7), 155-168.
Farah M. Muhammad, Bushra A. Khairallah, K. A. Albadrany. (2024). Synthesis, characterization and Antibacterial Evaluation of Novel 1,3-Oxazepine Derivatives Using A Cycloaddition Approach, Journal of Angiotherapy, 8(3), 1-9, 9506
Faraj, E. M., & Jumaa, F. H. (2022). Preparation, diagnostics and biological evaluation of new Schiff base and tetrazole derivatives. Materials Today: Proceedings, 49, 3549-3557.
Jumaa, F. H. (2018). Preparation, Identification and study Antibacterial Activity of Some new 2, 3-Dihydroquinazolin-4 (1H)-one Derivatives. Tikrit Journal of Pure Science, 23(9), 51-60.
Jumaa, F. H., Yass, I. A., & Ibrahim, B. K. (2023). Synthesis, Study of Their Liquid Crystal, Laser Properties of New Binary 1, 3-Oxazepine-4, 7-dione Derivatives and Evaluation of the Antibacterial Activity of Some of Them. Journal of Global Scientific Research, 8(9), 3201-3214.
Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
Magesh, M., Keerthika, B., Bharathi, D., Premavathi, K., Vijayalakshmi, M. K., & Lavanya, M. (2023). Overview of the Biological Activities of Quinazolines. Journal of Coastal Life Medicine, 11, 1879-1887.
Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
NAJM, R. S. (2019). Synthesis and biological activity evaluation of some new pyrazole derivatives. International Journal of Pharmaceutical Research, 11(1).
Owed, A. I., Al-Jubouri, A. A., & Al-Samarrai, S. Y. (2024). A nano-sensor for copper oxide was manufactured and developed using a new organic precipitant via green chemistry methods. Sensors and Machine Learning Applications, 1(1).
Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
Saleh, M. M., Saleh, J. N., Rokan, F. F., & Saleh, M. J. (2024). Synthesis, Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex [Co (2-(benzo [d] thiazol-2-yloxy) acetohydrazide)(H2O)(Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4).
Saleh, M. M. Amenah l. Al-Nassiry, Jamil Nadhem Saleh, & Mohammed Jwher Saleh.(2024). Preparation and Diagnosis of New Complexes for Hg (II) With 4-Amino Acetanilide And (Dppp) As A Ligand And Study Of The Bacterial Efficacy And Molecular Docking Of The Prepared Complexes. Central Asian Journal of Theoretical and Applied Science, 5(4), 364-373.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., & Al-Jubori, H. M. S. (2024). Synthesis and Characterization of Some New Imine Graphene Derivatives and Evaluation of Their Biological Activity. Central Asian Journal of Medical and Natural Science, 5(4), 272-290.
Talluh, A. W. A. S., Najm, R. S., Saleh, M. J., & Saleh, J. N. (2024). Synthesis, Characterization, and Evaluation of the Biological Activity of Novel Oxazepine Compounds Derived From Indole-5-Carboxylic Acid. American Journal of Bioscience and Clinical Integrity, 1(8), 10-19.
Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.
Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
Published
2024-09-23
How to Cite
Sabri, S. S., & Jumaa, F. H. (2024). Synthesis and Characterization of New Derivatives of 2,3-Dihydroquinazolin-4-one and Evaluation of their Antibacterial Activity . Central Asian Journal of Theoretical and Applied Science, 5(5), 483-490. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1497
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Articles
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