Study of the Bacterial Efficacy of Some Hg(II) Complexes with S-(thiophene-2-yl)2-((2-hydroxyphenyl)amino) Ethanethiol and Phosphines as Ligands
Abstract
This research involved the use of thiophene-2-thiol as a nucleus to create the ligand S-(thiophene-2-yl)2-((2-hydroxyphenyl)amino)ethanethiol (AZ2), a transition compound in the creation of many complexes. The complexes [[Hg(AZ2)(dppp)]Cl2] and [Hg(AZ2)(dppm)]Cl2] were created by combining the ligand with mercuric chloride and phosphine compounds. The structures of the intended compounds were confirmed by physical and spectroscopic methods such as infrared spectra and proton and carbon nuclear magnetic resonance (1H, 13C, 13P-NMR) spectra. The biological activity was evaluated using antibiotic-resistant bacteria, E. coli, Gram-negative (G-negative), and S. aureus, Gram-positive (G-positive). These organisms were compared with the antibiotic as a control (Controls), amoxicillin. The results showed a practical inhibitory effect against two different types of bacteria and a high degree of efficacy and specificity.
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