Synthesis and Characterization of New Some Imidazole’s Derivatives as Antioxidants
Keywords:
Imidazole, Antioxidant, Primary Amine, Aldehyde
Abstract
This research focuses on the synthesis and characterization of two new imidazole derivatives: 2-methoxy-6-[4-(naphthalen-2-yl)-1-phenyl-1H-imidazol-2-yl] and 2-(4-methylphenyl)-4-(naphthalen-2-yl)-1-phenyl-1H-imidazole. The study aimed to explore their antioxidant properties using DPPH radical scavenging assays. The synthesis was achieved by heating a mixture of 2-bromo-2′-acetonaphthone, primary amine, aldehyde, and ammonium acetate in a solvent-free environment at 130°C. The characterization of the compounds was done using FT-IR, 1H-NMR, and mass spectral analysis. The antioxidant activity was evaluated, and both derivatives demonstrated significant radical scavenging properties, with the second compound showing higher inhibition. The results suggest that these imidazole derivatives are potent antioxidants, which could be beneficial for further medicinal applications.
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Auhood Kadhim Zaid, Synthesis, Characterization, and Computational, Biological Studies of Four-membered Cyclic Amides 2- azetinones, Journal of Chemical Health Risks (2022) 12(4), 665-674
Rafid Ryyis Arraq; Angham G. Hadi, Synthesis, Identification, and Anti-oxidant Activity of Di-Organotin (IV) Cephalexin Complexes, Journal of Medicinal and Chemical Sciences,Volume 6, Issue 2 , February 2023, Pages 392-401 http://dx.doi.org/10.26655/JMCHEMSCI.2023.2.19
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Hayal M.Y., Magtoof M.S., Synthesis, Characterization of some New 4-Thiazolidinone of Acenaphthoquinone, University of Thi-Qar Journal of Science, 2021, 8:76
Amita V, Sunil J, and Deepika S, J Chem , 2013, 329412, 12 pages.
Zainab Amer Salla , University of Thi-Qar journal of science, 2020,vol7(2):87-89.
Vijesh A.M., Isloor A.M., Telkar S.,.Peethambar S.K, Rai S., and Isloor N., Euro J Medl Chem, 2011 ,. 46, no. 8, pp.3531–3536,
Singh BK, Mishra M, Saxenaa N, Yadav GP, Maulik PR, Sahoo MK,Gaur
RL, Murthy PK, Tripathi RP ,Eur J Med Chem,2008, 43:2717–2723
Sorrenti V., Salerno L., Di Giacomo C., Acquaviva R., Siracusa M.A., Vanella A. , Nitric Oxide , 2006,14: 45–50
Ali A. Abbas; Zainab N. Mageed; Olfat A. Nief; Hamid H. Mohammed, Synthesis and Characterization of Schiff Bases Derived from 3-(4-methoxyphenyl) Acrylic Acid and 3-(Benzo[d][1,3]dioxol-5-yl) Acrylic Acid, Journal of Medicinal and Chemical Sciences,Volume 6, Issue 2 , February 2023, Pages 205-219 http://dx.doi.org/10.26655/JMCHEMSCI.2023.2.4
Chen CW, Ho CT ,J Agric Food Chem, 1995, 2:35–46
Jain A. K., Ravichandran V., Sisodiya M., and Agrawal R. K. Asian Pacific J Trop Med, 2010, 3, no. 6, pp. 471–474,.
Mehdi A. ; Samira A.; , Shahzad F.; Jafar A. D.; Peiman M. SYNLETT, 2009, No. 20, pp 3263–3266
A. A. Abdelhamid, “Synthesis of imidazole derivatives: Ester and hydrazide compounds with antioxidant activity using ionic liquid as an efficient catalyst,” J Heterocycl Chem, vol. 57, no. 2, pp. 676–685, 2020, doi: 10.1002/jhet.3808.
E. Noriega-Iribe, “In vitro and in silico screening of 2,4,5-Trisubstituted imidazole derivatives as potential xanthine oxidase and acetylcholinesterase inhibitors, antioxidant, and antiproliferative agents,” Applied Sciences (Switzerland), vol. 10, no. 8, 2020, doi: 10.3390/APP10082889.
Published
2024-10-12
How to Cite
Hayal, M., Anatheil, A., & Awadi, H. (2024). Synthesis and Characterization of New Some Imidazole’s Derivatives as Antioxidants. Central Asian Journal of Theoretical and Applied Science, 5(6), 542-549. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1505
Section
Articles
