Creation of Novel Heterocyclic Compounds from (Triazole) Derivatives and Assessment of Their Biological Functions
Keywords:
Triazole, Heterocyclic rings, Schiff bases, Biological activity, Hypersensitivity, Imiadazoldine, β-Lactam, Oxazepine
Abstract
Heterocyclic compounds containing a 1,2,4-triazole moiety have attracted significant scientific and medical interest due to their unique structure and wide-ranging applications in drug development, organic synthesis, and chemical biology. Despite their absence in nature, triazole derivatives are integral to various disciplines, yet their potential in antibacterial and antifungal therapies remains underexplored. This study aims to synthesize novel 1,2,4-triazole derivatives by modifying the antibiotic triazole and evaluate their structural and biological properties. Characterization was performed using FTIR, H-NMR, and melting point analyses. The antibacterial activity against Staphylococcus aureus, Bacillus spp., Escherichia coli, Pseudomonas aeruginosa, and antifungal activity against Candida albicans were tested at concentrations of 250–500 mg/mL. A delayed hypersensitivity skin test confirmed their non-allergenic properties. Results demonstrated significant antimicrobial efficacy, highlighting the potential of 1,2,4-triazoles in developing novel therapeutic agents. Future research should explore their detailed mechanisms of action and broader pharmaceutical applications.
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References
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[4] A. F. Kareem and H. T. Qhanim, "Antimicrobial study of imidazole derivative from pyrimidine," International Journal of Biological Chemistry, vol. 12, no. 4, 2020.
[5] R. A. Aldujaily, "Synthesis and characterization of some new lactam from azo," Oriental Journal of Chemistry, vol. 34, no. 1, pp. 371–380, 2018.
[6] Z. K. Al-Khazragie and B. K. Al-Salami, "Synthesis, characterization, and antioxidant, antimicrobial properties of novel 1,3,4-thiadiazoline and 1,3,4-selenadiazoline derivatives," Journal of Medicinal Chemistry, vol. 12, no. 1, 2022.
[7] N. Sultana, M. S. Arayne, S. B. S. Rizvi, U. Haroon, and M. A. Mesaik, "Synthesis, spectroscopic, and biological evaluation of some levofloxacin metal complexes," Medicinal Chemistry Research, vol. 22, pp. 1371–1377, 2013. [CrossRef]
[8] A. F. Kareem and S. A. Kadhum, "Antimicrobial study of azo-imidazole (five cycles) compounds," International Journal of Chemical Sciences, vol. 4, no. 2, pp. 97–104, 2017.
[9] A. K. Mahdi and N. M. Aljamali, "Heterocyclic derivatives with aspirin drug: Synthesis, characterization, and study of its effect on cancer cells," Journal of Pharmaceutical Sciences, vol. 6, no. 2, 2020.
[10] A. F. Kareem and S. F. Abbas, "Review: Processes of 1,3-dipolar cycloaddition in nucleoside, nucleotide, and bio-conjugation and its importance in medicinal chemistry," Pharmaceutical Chemistry Journal, vol. 15, no. 1, pp. 10–18, 2023.
[11] J. S. Barradas and M. I. Errea, "Imidazo[2,1-b]thiazole carbohydrate derivatives: Synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever," European Journal of Medicinal Chemistry, vol. 45, no. 8, pp. 3320–3328, 2010. doi: 10.1016/j.ejmech.2010.11.012
[12] A. F. Kareem and A. T. Al Sa'ady, "Preparation and analysis of heterocyclic rings made from thioxanthone derivatives: Methods of biological activity and thermal analysis," International Journal of Chemical Science and Technology, vol. 6, no. 11, 2023.
[13] M. A. Hosny, T. H. El-Sayed, and E. A. El-Sawi, "A new type of synthesis of 1,2,3-thiadiazole and cyclization, diazaphosphole derivatives," E-Journal of Chemistry, vol. 3, no. 9, pp. 1287–1276, 2012.
[14] A. F. Kareem, "Synthesis and chemical characterization of cycles from oxadiazol-indole derivatives," International Journal of Biology, Pharmacy, and Allied Sciences, vol. 5, no. 6, pp. 1455–1467, 2016.
[15] H. J. Shah and J. A. Chaudhari, "Synthesis, characterization, and biological studies of novel heterocyclic compounds," International Science Conference Proceedings, vol. 4, pp. 177–181, 2015.
[16] Y. Ozkay, I. Isikdag, Z. Incesu, and G. Akalin, "Synthesis of 2-substituted–N-[4-(1-methyl-4,5-diphenyl-imidazole-2-yl)acetamide derivatives," European Journal of Medicinal Chemistry, vol. 45, no. 8, pp. 3320–3328, 2010.
[17] A. F. Kareem, S. A. Kadhum, and A. T. Al-Sa'ady, "Preparation of new mefenamic acid compounds and evaluation of the biological activities of their derivatives," Journal of Medicinal Chemistry, vol. 22, no. 1, pp. 147–154, 2023.
[18] M. Mustafa and M. B. Mushin, "Synthesis of fluconazole with pharm-chemical studying," Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 8, pp. 564–573, 2019.
[19] F. A. Nashaan, M. S. Al Rawi, A. H. Alhammer, A. M. Rabie, and J. H. Tomma, "Synthesis, characterization, and cytotoxic activity of some imides from galloyl hydrazide," Eurasian Chemical Communications, vol. 4, pp. 966–975, 2022. doi: 10.22034/ecc.2022.340135.1453
[20] A. T. Al Sa’ady, "Antibacterial screening for five local medicinal plants against nosocomial pathogens: Klebsiella pneumoniae and Staphylococcus epidermidis," EurAsian Journal of BioSciences, vol. 14, pp. 553–559, 2020. [Online]. Available: http://www.ejobios.org/article/antibacterial-screening-for-five-local-medicinal-plants-against-nosocomial-pathogens-klebsiella-7528
Published
2024-11-21
How to Cite
Alsadoon, A. H. (2024). Creation of Novel Heterocyclic Compounds from (Triazole) Derivatives and Assessment of Their Biological Functions. Central Asian Journal of Theoretical and Applied Science, 5(7), 622-629. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1516
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Articles
This work is licensed under a Creative Commons Attribution 4.0 International License.
