Synthesis and Identification of Novel 1,3-Oxazepane-7,4-Dione Compounds via the Reaction of Succinic Anhydride with Schiff's Base and Assessment of Biological Activity
Keywords:
Heterocyclic compounds, Schiff bases, oxazepane, biological activities
Abstract
This research showed how to use a cycloaddition method to make and describe new cyclic compounds, mainly oxazepine derivatives. Terephthalaldehyde and substituted aniline reacted with each other in an ethanol solvent under acidic conditions. Glacial acetic acid was used as a catalyst in this reaction. The final product was 1,1'-(1,4-phenylene)bis(N-substituted-methenamine) (H1-H6). We subsequently subjected these azomethines to pericyclic production in dry benzene using succinic anhydride, resulting in the production of 2,2'-(1,4-phenylene)bis(3-(substituted)-1,3-oxazepane-4,7-dione) (H7-H12). We employed the FT-IR, 1H-NMR, and 13C-NMR spectra to investigate the physicochemical properties of the produced compounds (H1 to H12). We tested the oxazepine compounds (H7, H8, H9, H10, H11, and H12) against different types of bacteria, such as gram-positive (Staphylococcus aureus) and gram-negative (E. coli), to see how well they worked against bacteria compared to common antibiotics like ciprofloxacin and norfloxacin. We employed three concentrations in DMSO: (0.01, 0.001, and 0.0001) mg/ml. The compounds They exhibited the most potent antibacterial activity against Staphylococcus aureus and Escherichia coli. This implies their potential for use as antimicrobials.
Downloads
Download data is not yet available.
References
A. Mermer, T. Keles, and Y. Sirin, "Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review," Bioorganic Chemistry, vol. 114, p. 105076, 2021. https://doi.org/10.1016/j.bioorg.2021.105076.
P. Arora, V. Arora, H. Lamba, and D. Wadhwa, "Importance of heterocyclic chemistry: A review," International Journal of Pharmaceutical Sciences and Research, vol. 3, p. 2947, 2012.
S. Wang, X.-H. Yuan, S.-Q. Wang, W. Zhao, X.-B. Chen, and B. Yu, "FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application," European Journal of Medicinal Chemistry, vol. 214, p. 113218, 2021. https://doi.org/10.1016/j.ejmech.2021.113218.
B. Eftekhari-Sis, M. Zirak, and A. Akbari, "Arylglyoxals in synthesis of heterocyclic compounds," Chemical reviews, vol. 113, pp. 2958-3043, 2013. https://doi.org/10.1021/cr300176g.
M. S. Saini, A. Kumar, J. Dwivedi, and R. Singh, "A review: biological significances of heterocyclic compounds," Int. J. Pharm. Sci. Res, vol. 4, pp. 66-77, 2013.
M. Fesatidou, A. Petrou, and G. Athina, "Heterocycle compounds with antimicrobial activity," Current pharmaceutical design, vol. 26, pp. 867-904, 2020. https://doi.org/10.2174/1381612826666200206093815.
C. Geethapriya and K. Elumalaiim, "Mannichbases: An Overview of Heterocyclic Compound with Various Biological Activities," heterocycles, vol. 18, p. 24, 2021.
J. Baranwal, S. Kushwaha, S. Singh, and A. Jyoti, "A review on the synthesis and pharmacological activity of heterocyclic compounds," Current Physical Chemistry, vol. 13, pp. 2-19, 2023. https://doi.org/10.2174/1877946813666221021144829.
H. Schiff, "Mittheilungen aus dem Universitätslaboratorium in Pisa: eine neue Reihe organischer Basen," Justus Liebigs Annalen der Chemie, vol. 131, pp. 118-119, 1864. https://doi.org/10.1002/jlac.18641310113.
E. Raczuk, B. Dmochowska, J. Samaszko-Fiertek, and J. Madaj, "Different Schiff bases—structure, importance and classification," Molecules, vol. 27, p. 787, 2022. https://doi.org/10.3390/molecules27030787.
S. S. Shah, D. Shah, I. Khan, S. Ahmad, U. Ali, and A. Rahman, "Synthesis and antioxidant activities of Schiff bases and their complexes: An updated review," Biointerface Res. Appl. Chem, vol. 10, pp. 6936-6963, 2020. https://doi.org/10.33263/BRIAC106.69366963.
W. AL-Kattan and E. AL-Nidaa, "Synthesis and characterization of Mn (II), Co (II), Ni (II) and Cu (II) complexes with Schiff bases derived from terephthalaldehyde and isophthalaldehyde," Journal of Education and Science, vol. 27, pp. 16-26, 2014.
K. Meena and P. Kumar Baroliya, "Synthesis, Characterization, Antimicrobial and Antimalarial Activities of Azines Based Schiff Bases and their Pd (II) Complexes," Chemistry & Biodiversity, vol. 20, p. e202300158, 2023. https://doi.org/10.1002/cbdv.202300158.
Y. Dong, M. Li, Y. Hao, Y. Feng, Y. Ren, and H. Ma, "Antifungal Activity, Structure‐Activity Relationship and Molecular Docking Studies of 1, 2, 4‐Triazole Schiff Base Derivatives," Chemistry & Biodiversity, vol. 20, p. e202201107, 2023. https://doi.org/10.1002/cbdv.202201107.
J. Jorge, K. F. Del Pino Santos, F. Timóteo, R. R. Piva Vasconcelos, O. Ignacio Ayala Cáceres, I. Juliane Arantes Granja, et al., "Recent advances on the antimicrobial activities of Schiff bases and their metal complexes: An updated overview," Current Medicinal Chemistry, vol. 31, pp. 2330-2344, 2024. https://doi.org/10.2174/0929867330666230224092830.
G. Hu, G. Wang, N. Duan, X. Wen, T. Cao, S. Xie, et al., "Design, synthesis and antitumor activities of fluoroquinolone C-3 heterocycles (IV): s-triazole Schiff–Mannich bases derived from ofloxacin," Acta Pharmaceutica Sinica B, vol. 2, pp. 312-317, 2012. https://doi.org/10.1016/j.apsb.2011.11.003.
N. El-wakiel, M. El-keiy, and M. Gaber, "Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu (II), Ni (II) and Co (II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1, 3-diol," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 147, pp. 117-123, 2015. https://doi.org/10.1016/j.saa.2015.03.020.
Q.-U.-A. Sandhu, M. Pervaiz, A. Majid, U. Younas, Z. Saeed, A. Ashraf, et al., "Schiff base metal complexes as anti-inflammatory agents," Journal of Coordination Chemistry, vol. 76, pp. 1094-1118, 2023. https://doi.org/10.1080/00958972.2023.2226794.
Y. Bayeh, F. Mohammed, M. Gebrezgiabher, F. Elemo, M. Getachew, and M. Thomas, "Synthesis, characterization and antibacterial activities of polydentate Schiff bases, based on salicylaldehyde," Advances in Biological Chemistry, vol. 10, pp. 127-139, 2020. https://doi.org/10.4236/abc.2020.105010.
S. Hosny, M. S. Ragab, and R. F. Abd El-Baki, "Synthesis of a new sulfadimidine Schiff base and their nano complexes as potential anti-COVID-19 and anti-cancer activity," Scientific Reports, vol. 13, p. 1502, 2023. https://doi.org/10.1038/s41598-023-28402-9.
G. Matela, "Schiff bases and complexes: a review on anti-cancer activity," Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), vol. 20, pp. 1908-1917, 2020. https://doi.org/10.2174/1871520620666200507091207.
A. M. M. Faisca Phillips and A. J. Pombeiro, "Modern Methods for the Synthesis of 1, 4‐Oxazepanes and Their Benzo‐Derivatives," Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, pp. 437-500, 2020. https://doi.org/10.1002/9781119708841.ch15.
S. A. Hassan, D. M. Aziz, M. N. Abdullah, A. R. Bhat, R. S. Dongre, S. Ahmed, et al., "Design and synthesis of oxazepine derivatives from sulfonamide Schiff bases as antimicrobial and antioxidant agents with low cytotoxicity and hemolytic prospective," Journal of Molecular Structure, vol. 1292, p. 136121, 2023.
H. M. S. Al-Jubori, "Preparation and Characterization of Some 1, 3-Oxazepane-7, 4-Dione Derivatives and Evaluation of their Biological Activity," EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, vol. 4, pp. 333-343, 2024. https://doi.org/10.47134/ejmmp.v4i9.
F. M. Muhammad, "Synthesis, Diagnosis And Evaluation Of The Antibacterial Activity Of New Oxazepane Derivatives," American Journal of Bioscience and Clinical Integrity, vol. 1, pp. 9-18, 2024. https://biojournals.us/index.php/AJBCI.
S. Abbas, H. Hanoon, Z. Abbas, K. Hussein, and S. Radhi, "Synthesis, spectral characteristics, and biological activity of 1, 3-oxazepines and 1, 3-oxazepanes Derived from 6-nitrobenzothiazol-2-amine," Russian Journal of Organic Chemistry, vol. 56, pp. 327-331, 2020.
A. G. Sager, J. K. Abaies, and Z. R. Katoof, "Molecular Docking, Synthesis and Evaluation for Antioxidant and Antibacterial Activity of New Oxazepane and Benzoxazepine Derivatives," Baghdad Science Journal, 2023. https://doi.org/10.21123/bsj.2023.8553.
A. Kumar, P. Kumar, S. Suhasini, P. Chaithanya, G. D. Rajesh, S. Suhasini, et al., "In-silico approach towards thiophene incorporated 1, 3-oxazepine using 5-HTT and 5-HT2AR receptors for antidepressant activity," Journal of Applied Pharmaceutical Science, vol. 13, pp. 190-200, 2023. https://doi.org/10.7324/JAPS.2023.152093.
H. S. Kahait, "Synthesis, Characterization and Biological Activity of Some New Heterocyclic Compounds Containing Azo group," Journal of Kufa for Chemical Sciences, vol. 2, pp. 27-39, 2021. https://doi.org/10.36329/jkcm/2024/v3.i2.12069.
Q. Weng, J. Yi, X. Chen, D. Luo, Y. Wang, W. Sun, et al., "Controllable synthesis and biological application of schiff bases from D-glucosamine and terephthalaldehyde," ACS omega, vol. 5, pp. 24864-24870, 2020. https://doi.org/10.1021/acsomega.0c03591.
Y. K. Alasadi, F. H. Jumaa, M. G. Mukhlif, and S. M. Shawkat, "Preparation, Characterization, Anticancer and Antibacterial Evaluation of New Schiff base and Tetrazole Derivatives," Tikrit Journal of Pure Science, vol. 28, pp. 12-19, 2023. https://doi.org/10.25130/tjps.v28i2.1333.
M. M. Al-Tufah, S. Beebaeny, S. S. Jasim, and B. L. Mohammed, "Synthesis, Characterization of Ethyl Dioxoisoindolinyl Cyclohexenone Carboxylate Derivatives from Some Chalcones and its Biological Activity Assessment," ed: Methodol, 2023.
M. J. Saleh and K. A. Al-Badrany, "Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation," Central Asian Journal of Medical and Natural Science, vol. 4, pp. 222-230, 2023. https://doi.org/10.17605/cajmns.v4i4.1691.
I. A. Hussein, S. F. Narren, I. M. M. Hasan, and A. M. Saleh, "Synthesis and biological activities of some new derivatives based on bis (4, 4'-diamino phenoxy) ethane containing Oxazpines, Terazole rings," Journal of Pharmaceutical Sciences and Research, vol. 10, pp. 2461-2469, 2018.
N. D. Jaffer, "Synthesis, Characterization, and Evaluation of Antioxidant and Physical Properties of New Bifunctional Aromatic Monomers Containing Imine and Heterocyclic Rings in The Main Chain," Journal of Kufa for Chemical Sciences, vol. 3, pp. 395-414, 2023. DOI: https://doi.org/10.36329/jkcm/2023/v3.i1.13855.
M. G. Mukhlif, O. J. M. Al-Asafi, and A. K. Alywee, "Formation of new substituted (1, 3) oxazepine 1, 5-diones via reaction of Exo-3, 6-epoxy-1, 2, 3, 6-tetrahydrophthalic Anhydride with Schiff’s bases," in AIP Conference Proceedings, 2023. https://doi.org/10.1063/5.0118487.
L. V. Gavali, A. A. Mohammed, M. J. Al-Ogaili, S. H. Gaikwad, M. Kulkarni, R. Das, et al., "Novel terephthalaldehyde bis (thiosemicarbazone) Schiff base ligand and its transition metal complexes as antibacterial Agents: Synthesis, characterization and biological investigations," Results in Chemistry, vol. 7, p. 101316, 2024. https://doi.org/10.1016/j.rechem.2024.101316.
M. Rohde, "The Gram-positive bacterial cell wall," Microbiology Spectrum, vol. 7, pp. 10.1128/microbiolspec. gpp3-0044-2018, 2019. https://doi.org/10.1128/9781555819323.ch17.
F. M. Muhammad, B. A. Khairallah, and K. Albadrany, "Synthesis, characterization and Antibacterial Evaluation of Novel 1, 3-Oxazepine Derivatives Using A Cycloaddition Approach," Journal of Angiotherapy, vol. 8, pp. 1-5, 2024. https://doi.org/10.25163/angiotherapy.839506.
P. Arora, V. Arora, H. Lamba, and D. Wadhwa, "Importance of heterocyclic chemistry: A review," International Journal of Pharmaceutical Sciences and Research, vol. 3, p. 2947, 2012.
S. Wang, X.-H. Yuan, S.-Q. Wang, W. Zhao, X.-B. Chen, and B. Yu, "FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application," European Journal of Medicinal Chemistry, vol. 214, p. 113218, 2021. https://doi.org/10.1016/j.ejmech.2021.113218.
B. Eftekhari-Sis, M. Zirak, and A. Akbari, "Arylglyoxals in synthesis of heterocyclic compounds," Chemical reviews, vol. 113, pp. 2958-3043, 2013. https://doi.org/10.1021/cr300176g.
M. S. Saini, A. Kumar, J. Dwivedi, and R. Singh, "A review: biological significances of heterocyclic compounds," Int. J. Pharm. Sci. Res, vol. 4, pp. 66-77, 2013.
M. Fesatidou, A. Petrou, and G. Athina, "Heterocycle compounds with antimicrobial activity," Current pharmaceutical design, vol. 26, pp. 867-904, 2020. https://doi.org/10.2174/1381612826666200206093815.
C. Geethapriya and K. Elumalaiim, "Mannichbases: An Overview of Heterocyclic Compound with Various Biological Activities," heterocycles, vol. 18, p. 24, 2021.
J. Baranwal, S. Kushwaha, S. Singh, and A. Jyoti, "A review on the synthesis and pharmacological activity of heterocyclic compounds," Current Physical Chemistry, vol. 13, pp. 2-19, 2023. https://doi.org/10.2174/1877946813666221021144829.
H. Schiff, "Mittheilungen aus dem Universitätslaboratorium in Pisa: eine neue Reihe organischer Basen," Justus Liebigs Annalen der Chemie, vol. 131, pp. 118-119, 1864. https://doi.org/10.1002/jlac.18641310113.
E. Raczuk, B. Dmochowska, J. Samaszko-Fiertek, and J. Madaj, "Different Schiff bases—structure, importance and classification," Molecules, vol. 27, p. 787, 2022. https://doi.org/10.3390/molecules27030787.
S. S. Shah, D. Shah, I. Khan, S. Ahmad, U. Ali, and A. Rahman, "Synthesis and antioxidant activities of Schiff bases and their complexes: An updated review," Biointerface Res. Appl. Chem, vol. 10, pp. 6936-6963, 2020. https://doi.org/10.33263/BRIAC106.69366963.
W. AL-Kattan and E. AL-Nidaa, "Synthesis and characterization of Mn (II), Co (II), Ni (II) and Cu (II) complexes with Schiff bases derived from terephthalaldehyde and isophthalaldehyde," Journal of Education and Science, vol. 27, pp. 16-26, 2014.
K. Meena and P. Kumar Baroliya, "Synthesis, Characterization, Antimicrobial and Antimalarial Activities of Azines Based Schiff Bases and their Pd (II) Complexes," Chemistry & Biodiversity, vol. 20, p. e202300158, 2023. https://doi.org/10.1002/cbdv.202300158.
Y. Dong, M. Li, Y. Hao, Y. Feng, Y. Ren, and H. Ma, "Antifungal Activity, Structure‐Activity Relationship and Molecular Docking Studies of 1, 2, 4‐Triazole Schiff Base Derivatives," Chemistry & Biodiversity, vol. 20, p. e202201107, 2023. https://doi.org/10.1002/cbdv.202201107.
J. Jorge, K. F. Del Pino Santos, F. Timóteo, R. R. Piva Vasconcelos, O. Ignacio Ayala Cáceres, I. Juliane Arantes Granja, et al., "Recent advances on the antimicrobial activities of Schiff bases and their metal complexes: An updated overview," Current Medicinal Chemistry, vol. 31, pp. 2330-2344, 2024. https://doi.org/10.2174/0929867330666230224092830.
G. Hu, G. Wang, N. Duan, X. Wen, T. Cao, S. Xie, et al., "Design, synthesis and antitumor activities of fluoroquinolone C-3 heterocycles (IV): s-triazole Schiff–Mannich bases derived from ofloxacin," Acta Pharmaceutica Sinica B, vol. 2, pp. 312-317, 2012. https://doi.org/10.1016/j.apsb.2011.11.003.
N. El-wakiel, M. El-keiy, and M. Gaber, "Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu (II), Ni (II) and Co (II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1, 3-diol," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 147, pp. 117-123, 2015. https://doi.org/10.1016/j.saa.2015.03.020.
Q.-U.-A. Sandhu, M. Pervaiz, A. Majid, U. Younas, Z. Saeed, A. Ashraf, et al., "Schiff base metal complexes as anti-inflammatory agents," Journal of Coordination Chemistry, vol. 76, pp. 1094-1118, 2023. https://doi.org/10.1080/00958972.2023.2226794.
Y. Bayeh, F. Mohammed, M. Gebrezgiabher, F. Elemo, M. Getachew, and M. Thomas, "Synthesis, characterization and antibacterial activities of polydentate Schiff bases, based on salicylaldehyde," Advances in Biological Chemistry, vol. 10, pp. 127-139, 2020. https://doi.org/10.4236/abc.2020.105010.
S. Hosny, M. S. Ragab, and R. F. Abd El-Baki, "Synthesis of a new sulfadimidine Schiff base and their nano complexes as potential anti-COVID-19 and anti-cancer activity," Scientific Reports, vol. 13, p. 1502, 2023. https://doi.org/10.1038/s41598-023-28402-9.
G. Matela, "Schiff bases and complexes: a review on anti-cancer activity," Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), vol. 20, pp. 1908-1917, 2020. https://doi.org/10.2174/1871520620666200507091207.
A. M. M. Faisca Phillips and A. J. Pombeiro, "Modern Methods for the Synthesis of 1, 4‐Oxazepanes and Their Benzo‐Derivatives," Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, pp. 437-500, 2020. https://doi.org/10.1002/9781119708841.ch15.
S. A. Hassan, D. M. Aziz, M. N. Abdullah, A. R. Bhat, R. S. Dongre, S. Ahmed, et al., "Design and synthesis of oxazepine derivatives from sulfonamide Schiff bases as antimicrobial and antioxidant agents with low cytotoxicity and hemolytic prospective," Journal of Molecular Structure, vol. 1292, p. 136121, 2023.
H. M. S. Al-Jubori, "Preparation and Characterization of Some 1, 3-Oxazepane-7, 4-Dione Derivatives and Evaluation of their Biological Activity," EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, vol. 4, pp. 333-343, 2024. https://doi.org/10.47134/ejmmp.v4i9.
F. M. Muhammad, "Synthesis, Diagnosis And Evaluation Of The Antibacterial Activity Of New Oxazepane Derivatives," American Journal of Bioscience and Clinical Integrity, vol. 1, pp. 9-18, 2024. https://biojournals.us/index.php/AJBCI.
S. Abbas, H. Hanoon, Z. Abbas, K. Hussein, and S. Radhi, "Synthesis, spectral characteristics, and biological activity of 1, 3-oxazepines and 1, 3-oxazepanes Derived from 6-nitrobenzothiazol-2-amine," Russian Journal of Organic Chemistry, vol. 56, pp. 327-331, 2020.
A. G. Sager, J. K. Abaies, and Z. R. Katoof, "Molecular Docking, Synthesis and Evaluation for Antioxidant and Antibacterial Activity of New Oxazepane and Benzoxazepine Derivatives," Baghdad Science Journal, 2023. https://doi.org/10.21123/bsj.2023.8553.
A. Kumar, P. Kumar, S. Suhasini, P. Chaithanya, G. D. Rajesh, S. Suhasini, et al., "In-silico approach towards thiophene incorporated 1, 3-oxazepine using 5-HTT and 5-HT2AR receptors for antidepressant activity," Journal of Applied Pharmaceutical Science, vol. 13, pp. 190-200, 2023. https://doi.org/10.7324/JAPS.2023.152093.
H. S. Kahait, "Synthesis, Characterization and Biological Activity of Some New Heterocyclic Compounds Containing Azo group," Journal of Kufa for Chemical Sciences, vol. 2, pp. 27-39, 2021. https://doi.org/10.36329/jkcm/2024/v3.i2.12069.
Q. Weng, J. Yi, X. Chen, D. Luo, Y. Wang, W. Sun, et al., "Controllable synthesis and biological application of schiff bases from D-glucosamine and terephthalaldehyde," ACS omega, vol. 5, pp. 24864-24870, 2020. https://doi.org/10.1021/acsomega.0c03591.
Y. K. Alasadi, F. H. Jumaa, M. G. Mukhlif, and S. M. Shawkat, "Preparation, Characterization, Anticancer and Antibacterial Evaluation of New Schiff base and Tetrazole Derivatives," Tikrit Journal of Pure Science, vol. 28, pp. 12-19, 2023. https://doi.org/10.25130/tjps.v28i2.1333.
M. M. Al-Tufah, S. Beebaeny, S. S. Jasim, and B. L. Mohammed, "Synthesis, Characterization of Ethyl Dioxoisoindolinyl Cyclohexenone Carboxylate Derivatives from Some Chalcones and its Biological Activity Assessment," ed: Methodol, 2023.
M. J. Saleh and K. A. Al-Badrany, "Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation," Central Asian Journal of Medical and Natural Science, vol. 4, pp. 222-230, 2023. https://doi.org/10.17605/cajmns.v4i4.1691.
I. A. Hussein, S. F. Narren, I. M. M. Hasan, and A. M. Saleh, "Synthesis and biological activities of some new derivatives based on bis (4, 4'-diamino phenoxy) ethane containing Oxazpines, Terazole rings," Journal of Pharmaceutical Sciences and Research, vol. 10, pp. 2461-2469, 2018.
N. D. Jaffer, "Synthesis, Characterization, and Evaluation of Antioxidant and Physical Properties of New Bifunctional Aromatic Monomers Containing Imine and Heterocyclic Rings in The Main Chain," Journal of Kufa for Chemical Sciences, vol. 3, pp. 395-414, 2023. DOI: https://doi.org/10.36329/jkcm/2023/v3.i1.13855.
M. G. Mukhlif, O. J. M. Al-Asafi, and A. K. Alywee, "Formation of new substituted (1, 3) oxazepine 1, 5-diones via reaction of Exo-3, 6-epoxy-1, 2, 3, 6-tetrahydrophthalic Anhydride with Schiff’s bases," in AIP Conference Proceedings, 2023. https://doi.org/10.1063/5.0118487.
L. V. Gavali, A. A. Mohammed, M. J. Al-Ogaili, S. H. Gaikwad, M. Kulkarni, R. Das, et al., "Novel terephthalaldehyde bis (thiosemicarbazone) Schiff base ligand and its transition metal complexes as antibacterial Agents: Synthesis, characterization and biological investigations," Results in Chemistry, vol. 7, p. 101316, 2024. https://doi.org/10.1016/j.rechem.2024.101316.
M. Rohde, "The Gram-positive bacterial cell wall," Microbiology Spectrum, vol. 7, pp. 10.1128/microbiolspec. gpp3-0044-2018, 2019. https://doi.org/10.1128/9781555819323.ch17.
F. M. Muhammad, B. A. Khairallah, and K. Albadrany, "Synthesis, characterization and Antibacterial Evaluation of Novel 1, 3-Oxazepine Derivatives Using A Cycloaddition Approach," Journal of Angiotherapy, vol. 8, pp. 1-5, 2024. https://doi.org/10.25163/angiotherapy.839506.
Published
2025-01-20
How to Cite
M.Al- Tufah, M. (2025). Synthesis and Identification of Novel 1,3-Oxazepane-7,4-Dione Compounds via the Reaction of Succinic Anhydride with Schiff’s Base and Assessment of Biological Activity. Central Asian Journal of Theoretical and Applied Science, 6(1), 34-51. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/1535
Section
Articles
