Цинк И Заживление Ран: Обзор Физиологии И Клинического Применения
Keywords:
заживление ран, дефицит цинка, добавки цинка
Abstract
: В настоящее время проводятся ряд исследований для изучения функций цинка в организме человека, однако имеются серьезные пробелы в отношении функции цинка в заживлении ран. Этот обзор направлен на то, чтобы предоставить клиницисту достаточное понимание биохимии цинка и современный взгляд на роль цинка в заживлении ран. Цинк является незаменимым элементом, который имеет решающее значение для поддержания нормальной физиологии, а его дефицит имеет множество проявлений, начиная от замедленного заживления ран и заканчивая иммунной дисфункцией и нарушением многих сенсорных систем. Хотя был достигнут консенсус в отношении отрицательного действия дефицита цинка в заживлении ран в литературе существуют значительные разногласия по поводу оптимальных методов и реальных преимуществ добавок цинка.
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References
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31. Lansdown AB. Influence of zinc oxide in the closure of open skin wounds. Int J Cosmet Sci. 1993;15(2):83–85.
32. Agren MS. Zinc oxide increases degradation of collagen in necrotic wound tissue. Br J Dermatol. 1993;129(2): 221-222.
33. Mirastschijski U, Haaksma CJ, Tomasek JJ, Agren MS. Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds. Exp Cell Res. 2004;299(2):465–475.
34. Sandstead HH, Lanier VC Jr, Shephard GH, Gillespie DD. Zinc and wound healing. Effects of zinc deficiency and zinc supplementation. Am J Clin Nutr. 1970;23(5):514–519.
35. Hallmans G, Lasek J. The effect of topical zinc absorption from wounds on growth and the wound healing process in zinc-deficient rats. Scand J Plast Reconstr Surg. 1985;19(2):119–125.
36. Agren MS, Chvapil M, Franzen L. Enhancement of re-epithelialization with topical zinc oxide in porcine partial-thickness wounds. J Surg Res. 1991;50(2):101–105.
37. Agren MS. Zinc in wound repair. Arch Dermatol. 1999; 135(10):1273–1274.
38. Tarnow P, Agren M, Steenfos H, Jansson JO. Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds. Scand J Plast Reconstr Surg Hand Surg. 1994;28(4):255–259.
39. Shenkin A. Trace elements and inflammatory response: implications for nutritional support. Nutrition. 1995;11 (1 Suppl):100–105.
40. Gaetke LM, McClain CJ, Talwalkar RT, Shedlofsky SI. Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol. 1997;272(6 Pt 1):E952–E956.
41. Henzel JH, DeWeese MS, Lichti EL. Zinc concentrations within healing wounds. Significance of postoperative zincuria on availability and requirements during tissue repair. Arch Surg. 1970; 100(4):349–357.
42. Philcox JC, Coyle P, Michalska A, Choo KH, Rofe AM. Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression. Biochem J. 1995;308(Pt 2):543–546.
43. Wilkinson EA, Hawke CI. Does oral zinc aid the healing of chronic leg ulcers? A systematic literature review. Arch Dermatol. 1998;134(12):1556–1560.
44. Agren MS. Studies on zinc in wound healing. Acta Derm Venereol Suppl (Stockh). 1990;154:1–36.
45. Agren MS, Stromberg HE. Topical treatment of pressure ulcers. A randomized comparative trial of Varidase and zinc oxide. Scand J Plast Reconstr Surg. 1985;19(1):97–100.
46. Apelqvist J, Larsson J, Stenström A. Topical treatment of necrotic foot ulcers in diabetic patients: a comparative trial of DuoDerm and MeZinc. Br J Dermatol. 1990;123(6):787–792.
47. Gang RK. Adhesive zinc tape in burns: results of a clinical trial. Burns. 1981;7(5):322–325.
48. Berger MM, Cavadini C, Bart A, et al. Cutaneous copper and zinc losses in burns. Burns. 1992;18(5):373–380.
49. Caldis-Coutris N, Gawaziuk JP, Logsetty S. Zinc supplementation in burn patients. J Burn Care Res. 2012;33(5): 678–682.
50. Тухтаназарова Ш. И., Абдуллаева Д. Р., Маллаходжаев А. А. (2022).Поступление цинка с пищей и влияние добавок цинка на иммунную функцию у пожилых людей. European Journal of Interdisciplinary Research and Development, 3, 55–71.
2. Lutz RE. The normal occurrence of zinc in biologic materials: a review of the literature, and a study of the normal distribution of zinc in the rat, cat, and man. J Ind Hyg. 1926;8:177–207.
3. Drinker KR, Collier ES. The significance of zinc in the living organism. J Ind Hyg. 1926;8:267–269.
4. Keilin D, Mann T. Carbonic anhydrase. Nature. 1939;144 (3644):442–443.
5. Miller J, McLachlan AD, Klug A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 1985;4(6):1609–1614.
6. Finn RD, Tate J, Mistry J, et al. The Pfam protein families database [published online ahead of print November 17, 2009]. Nucleic Acids Res. 2010;38(Database issue): D211–D222.
7. Bertini I, Cavallaro G. Bioinformatics in bioinorganic chemistry [published online ahead of print September 29, 2009]. Metallomics. 2010;2(1):39–51.
8. Andreini C, Banci L, Bertini I, Rosato A. Zinc through the three domains of life. J Proteome Res. 2006;5(11): 3173–3178.
9. Maret W. Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr. 2013;4(1):82–91.
10. Fukada T, Kambe T. Molecular and genetic features of zinc transporters in physiology and pathogenesis [published online ahead of print May 13, 2011]. Metallomics. 2011;3(7):662–674.
11. Lichten LA, Cousins RJ. Mammalian zinc transporters: nutritional and physiologic regulation. Annu Rev Nutr. 2009;29:153–176.
12. Gaither LA, Eide DJ. Eukaryotic zinc transporters and their regulation. Biometals. 2001;14(3-4):251–270.
13. Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Arch Biochem Biophys. 2007; 463(2):201–210.
14. Günes C, Heuchel R, Georgiev O, et al. Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 1998; 17(10):2846–2854.
15. Li Y, Maret W. Human metallothionein metallomics. J Analytical Atomic Spectrom. 2008;23(8):1055–1062.
16. Tapiero H, Tew KD. Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother. 2003;57(9):399–411.
17. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998;68(2 Suppl):S447–S463.
18. Turnlund JR, King JC, Keyes WR, Gong B, Michel MC. A stable isotope study of zinc absorption in young men: effects of phytate and alpha-cellulose. Am J Clin Nutr. 1984;40(5):1071–1077.
19. Kenny F, Sriram K, Hammond JB. Clinical zinc deficiency during adequate enteral nutrition. J Am Coll Nutr. 1989;8(1):83–85.
20. Cousins RJ. Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev. 1985;65(2):238–309.
21. Livingstone C. Zinc: physiology, deficiency, and parenteral nutrition [published online ahead of print February 13, 2015]. Nutr Clin Pract. 2015;30(3):371–382.
22. Prasad AS. Clinical manifestations of zinc deficiency. Annu Rev Nutr. 1985;5:341–363.
23. Meydani SN, Leka LS, Fine BC, et al. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA. 2004;292(7):828–836.
24. Berger A. What does zinc do? BMJ. 2002;325(7372):1062.
25. Raffoul W, Far MS, Cayeux MC, Berger MM. Nutritional status and food intake in nine patients with chronic low-limb ulcers and pressure ulcers: importance of oral supplements. Nutrition. 2006;22(1):82–88.
26. Fosmire GJ. Zinc toxicity. Am J Clin Nutr. 1990;51(2): 225–227.
27. Lansdown AB, Sampson B, Rowe A. Sequential changes in trace metal, metallothionein and calmodulin concentrations in healing skin wounds. J Anat. 1999;195(Pt 3): 375–386.
28. Agren MS, Franzén L. Influence of zinc deficiency on breaking strength of 3-week-old skin incisions in the rat. Acta Chir Scand. 1990;156(10):667–670.
29. Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS. Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound Repair Regen. 2007;15(1):2–16.
30. Keefer K, Iocono J, Ehrlich H. Zinc-containing wound dressings encourage autolytic debridement of dermal burns. Wounds. 1998;10(2):54–58.
31. Lansdown AB. Influence of zinc oxide in the closure of open skin wounds. Int J Cosmet Sci. 1993;15(2):83–85.
32. Agren MS. Zinc oxide increases degradation of collagen in necrotic wound tissue. Br J Dermatol. 1993;129(2): 221-222.
33. Mirastschijski U, Haaksma CJ, Tomasek JJ, Agren MS. Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds. Exp Cell Res. 2004;299(2):465–475.
34. Sandstead HH, Lanier VC Jr, Shephard GH, Gillespie DD. Zinc and wound healing. Effects of zinc deficiency and zinc supplementation. Am J Clin Nutr. 1970;23(5):514–519.
35. Hallmans G, Lasek J. The effect of topical zinc absorption from wounds on growth and the wound healing process in zinc-deficient rats. Scand J Plast Reconstr Surg. 1985;19(2):119–125.
36. Agren MS, Chvapil M, Franzen L. Enhancement of re-epithelialization with topical zinc oxide in porcine partial-thickness wounds. J Surg Res. 1991;50(2):101–105.
37. Agren MS. Zinc in wound repair. Arch Dermatol. 1999; 135(10):1273–1274.
38. Tarnow P, Agren M, Steenfos H, Jansson JO. Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds. Scand J Plast Reconstr Surg Hand Surg. 1994;28(4):255–259.
39. Shenkin A. Trace elements and inflammatory response: implications for nutritional support. Nutrition. 1995;11 (1 Suppl):100–105.
40. Gaetke LM, McClain CJ, Talwalkar RT, Shedlofsky SI. Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol. 1997;272(6 Pt 1):E952–E956.
41. Henzel JH, DeWeese MS, Lichti EL. Zinc concentrations within healing wounds. Significance of postoperative zincuria on availability and requirements during tissue repair. Arch Surg. 1970; 100(4):349–357.
42. Philcox JC, Coyle P, Michalska A, Choo KH, Rofe AM. Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression. Biochem J. 1995;308(Pt 2):543–546.
43. Wilkinson EA, Hawke CI. Does oral zinc aid the healing of chronic leg ulcers? A systematic literature review. Arch Dermatol. 1998;134(12):1556–1560.
44. Agren MS. Studies on zinc in wound healing. Acta Derm Venereol Suppl (Stockh). 1990;154:1–36.
45. Agren MS, Stromberg HE. Topical treatment of pressure ulcers. A randomized comparative trial of Varidase and zinc oxide. Scand J Plast Reconstr Surg. 1985;19(1):97–100.
46. Apelqvist J, Larsson J, Stenström A. Topical treatment of necrotic foot ulcers in diabetic patients: a comparative trial of DuoDerm and MeZinc. Br J Dermatol. 1990;123(6):787–792.
47. Gang RK. Adhesive zinc tape in burns: results of a clinical trial. Burns. 1981;7(5):322–325.
48. Berger MM, Cavadini C, Bart A, et al. Cutaneous copper and zinc losses in burns. Burns. 1992;18(5):373–380.
49. Caldis-Coutris N, Gawaziuk JP, Logsetty S. Zinc supplementation in burn patients. J Burn Care Res. 2012;33(5): 678–682.
50. Тухтаназарова Ш. И., Абдуллаева Д. Р., Маллаходжаев А. А. (2022).Поступление цинка с пищей и влияние добавок цинка на иммунную функцию у пожилых людей. European Journal of Interdisciplinary Research and Development, 3, 55–71.
Published
2022-06-04
How to Cite
Ф. А, Ж., Ш. И, Т., Ж. Н., Д., У. У, С., С. Ж., Ф., & А. А, М. (2022). Цинк И Заживление Ран: Обзор Физиологии И Клинического Применения. Central Asian Journal of Theoretical and Applied Science, 3(6), 33-40. Retrieved from https://cajotas.centralasianstudies.org/index.php/CAJOTAS/article/view/596
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