Features of the Course of Cholelithis Disease in Elderly People with Diseases of the Internal Secretion Glands

Gaziev Karim Umarovich

Gaziev Karim Umarovich Candidate of Medical Sciences, Associate Professor of Faculty and Hospital Surgery department Bukhara State Medical Institute

Keywords: cholelithiasis, endocrine diseases, elderly parients

Abstract

The number of patients with cholelithiasis and endocrine pathology increase at eldery age. The patient’s age over 60 years is one of the risk factors of complications after cholecystectomy. The aim of this study is to investigate the effect of endocrine disorders on immediate results of surgical treatment of elderly patients with cholelithiasis. Materials & methods. 295 patients with cholelithiasis were operated on: 107 (36.3%) patients over 60 years (main group) and 188 (63.7%) patients younger than 60 years (control group). Results & discussion. The correlation between the age of the patients and severity of gallbladder’s inflammation was determined (r=0.176; p=0.002). The choledocholithiasis was diagnosed in 14 (13.1%) cases in the main group and in seven (3.7%) cases in the control group (p=0.003). Endocrine disorders were indicated at elderly patients more often (81.3% vs 67.7%; p=0.011). Open and conversion operations were performed at patients over 60 years more often (30.8% vs 9.0%; p<0.001). 14 (13.1%) patients of the main group and six (3.2%) patients of control group had postoperative complications (p=0.001). The hospital stay of elderly patients was longer (Me=10.0 days vs Me=8.0 days; p<0.001). The following correlations of elderly patients were established: between severity of gallbladder’s inflammation and waist circumference (r=0.239; p=0.013), between severity of gallbladder’s inflammation and the level of glucose (r=0.218; p=0.024), between severity of gallbladder’s inflammation and concentration of calcium (r=- 0.450; p<0.001); between the rate of purulent-inflammatory postoperative complications and the level of thyrotropic hormone (r=0.273; p=0.008), between the rate of purulent-inflammatory postoperative complications and hyperglycemia (r=0.211; p=0.029), between the rate of purulentinflammatory postoperative complications and open cholecystectomy (r=0.235; p=0.015); between hospital stay and waist circumference (r=0.197; p=0.047), between hospital stay and concentration of thyrotropic hormone (r=0.304; p=0.010), thyrotropic hormone and the level of calcium (r=-0.250; p=0.022). Conclusion. The endocrine disorders complicate the course of cholelithiasis at elderly patients that is accompanied by the increase of rates of postoperative complications and hospital stay..

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References

1. Titov V.V., Kalachev I.I., Timoshin A.D. Comparative assessment of sub- and supraponeurotic plastic surgery of the anterior abdominal wall in patients with postoperative ventral hernias // Annals of Surgery. 2008. No. 4. P. 56-59.
2. Khamdamov B.Z., Nuraliev N.A., Gaziev K.U., TeshaevSh.Zh., Khamdamov I.B. Experimental development of methods for local treatment of wound infection. // Biology va Tibbiyot Muammolari. 2020. No. 1, (116). – pp. 194-200.
3. Yagudin M.K. Alternative approaches to hernioplasty of postoperative ventral hernias // Kazan. honey. magazine 2003. No. 2. pp. 121-123.9. Busek J. et al. Retromuscular mesh repair of a hernia in a scar according to Rives our first experience // Rozhl. Chir. 2005. Vol. 84. P. 543-546.
4. Celdran A. et al. The role of antibiotic prophylaxis on wound infection after mesh hernia repair under local anesthesia on an ambulatory basis // Hernia. 2004. № 8. P. 20-22.
5. Hanna M., Dissanaike S. Mesh ingrowth with concomitant bacterial infection resulting in inability to explant: a failure of mesh salvage // Hernia 2015; 19 (2): 339-344.
6. Khamdamov B.Z., Dehonov A.T., Gaziev K.U., Khamdamov I.B., Khakimboyeva K.A. Characteristics of the Immune Profile in Wound Infection in Patients with Diabetes Mellitus.// American Journal of Medicine and Medical Sciences 2022, 12(4): 432-436
7. Hamdamov B.Z., Musoev T.Y., Khaidarov F.N., Gaziev K.U. Dynamics of cytokine blood profile at destructive forms of acute
calculous cholecystitis. // Europe's Journal of Psychology, 2021, Vol. 17(3), 93-101.
8. Salameh J. R. et al. Role of biomarkers in incisional hernias // Am. Surg. 2007. Vol. 73, № 6. P. 561-567.
9. Simchen T., Rozin R., Wax Y. The Israel Study of Surgical Infection of drains and risk of wound infection in operations for hernia // Surg. Gynecol. Obstet. 1990. Vol. 170, № 4. P. 331-337.
10. Gaziev K.U. Adaptive approach in the treatment of elderly and senile patients with postoperative ventral hernias. Journal of Pharmaceutical Negative Results, 4613–4616. https://doi.org/10.47750/pnr.2022.13.S07.574
11. Gaziyev K. (2023). Features of the tactics of treatment in adult patients with postoperative abdominal hernia. American Journal of Pediatric Medicine and Health Sciences, 1(4), 158–161. Retrieved from https://grnjournal.us/index.php/AJPMHS/article/view/275
12. Gaziyev, K. U. (2023). Impact of Endocrine Disorders on the Results of Surgical Treatment of Patients with Cholelithiasis of Elderly and Old Age. Central Asian Journal of Medical and Natural Science, 4(1), 182-186. https://doi.org/10.17605/OSF.IO/4RZ7W